Tier 1 — highest

Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials

Xi Zhang, Yufeng Li, Liana C Del Gobbo, Andrea Rosanoff, Jiawei Wang, Wen Zhang, Yiqing Song
Hypertension (Dallas, Tex. : 1979) 2016 68(2):324-33

Bibliography

PubMed
PMID 27402922
DOI
10.1161/HYPERTENSIONAHA.116.07664
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample34 randomized trials involving 2,028 adults
InterventionMedian elemental magnesium dose 368 mg/day
DurationMedian 3 months
EndpointsSystolic and diastolic blood pressure; Serum magnesium

What the study showed, in plain terms

This publication examines systolic and diastolic blood pressure, serum magnesium. Study population or evidence base: 34 randomized trials involving 2,028 adults. Intervention or exposure: Median elemental magnesium dose 368 mg/day.

Key findings

Pooled trials found average reductions of approximately 2 mmHg systolic and 1.8 mmHg diastolic blood pressure compared with placebo.

What this study can and cannot tell us

Trial populations, baseline blood pressure and regimens differed. These average effects at several hundred milligrams of elemental magnesium cannot be assumed for much lower elemental doses.

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