Tier 1 — highest

Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials

Nicola Veronese, Ligia J Dominguez, Damiano Pizzol, Jacopo Demurtas, Lee Smith, Mario Barbagallo
Nutrients 2021 13(11):4074

Bibliography

PubMed
PMID 34836329
PubMed Central
PMC8619199
DOI
10.3390/nu13114074
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample25 randomized trials: 13 in diabetes and 12 in populations at elevated diabetes risk
InterventionOral magnesium versus placebo; regimens varied
DurationVaried across included trials
EndpointsFasting glucose; Oral glucose tolerance; Insulin sensitivity

What the study showed, in plain terms

This publication examines fasting glucose, oral glucose tolerance, insulin sensitivity. Study population or evidence base: 25 randomized trials: 13 in diabetes and 12 in populations at elevated diabetes risk. Intervention or exposure: Oral magnesium versus placebo; regimens varied.

Key findings

The pooled evidence suggested improved fasting glucose in diabetes and favorable glucose or insulin-sensitivity measures in some high-risk populations.

What this study can and cannot tell us

Heterogeneous clinical populations and regimens. This analysis does not show that magnesium replaces diabetes treatment or that all formulations and doses have equal effects.

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