Tier 1 — highest

Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial

Elizabeth Sun, Xiangzhu Zhu, Reid M Ness, Harvey J Murff, Shan Sun, Chang Yu, Lei Fan, M Andrea Azcarate-Peril, Martha J Shrubsole, Qi Dai
The American journal of clinical nutrition 2025 122(5):1185-1194

Bibliography

PubMed
PMID 40946805
PubMed Central
PMC12799435
DOI
10.1016/j.ajcnut.2025.09.011
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
The authors report no dedicated external funding for this publication.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample226 participants with valid microbiome data from the PPCCT
InterventionPersonalized oral magnesium versus placebo, with TRPM7 genotype analysis
Duration12 weeks in the parent personalized-magnesium intervention
EndpointsGut bacterial abundance; Treatment–genotype interactions

What the study showed, in plain terms

This publication examines gut bacterial abundance, treatment–genotype interactions. Study population or evidence base: 226 participants with valid microbiome data from the PPCCT. Intervention or exposure: Personalized oral magnesium versus placebo, with TRPM7 genotype analysis.

Key findings

Magnesium increased selected bacterial taxa in participants with one TRPM7 genotype; responses differed by genotype. The most robust result concerned Carnobacterium abundance.

What this study can and cannot tell us

An exploratory microbiome analysis from the PPCCT, not direct evidence of colorectal-cancer prevention or increased human intestinal vitamin D production.

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