Tier 2 — strong

Impact of magnesium on bone health in older adults: A systematic review and meta-analysis

Inge Groenendijk, Marieke van Delft, Pieter Versloot, Luc J C van Loon, Lisette C P G M de Groot
Bone 2022 154:116233

Bibliography

PubMed
PMID 34666201
DOI
10.1016/j.bone.2021.116233
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis of observational studies
ModelHuman evidence synthesis
Sample12 observational studies; 4 contributed to the hip-density meta-analysis
InterventionMagnesium intake from dietary and other sources
DurationVaried by observational study
EndpointsBone mineral density; Bone mineral content; Fractures

What the study showed, in plain terms

This publication examines bone mineral density, bone mineral content, fractures. Study population or evidence base: 12 observational studies; 4 contributed to the hip-density meta-analysis. Intervention or exposure: Magnesium intake from dietary and other sources.

Key findings

Higher magnesium intake was associated with higher hip bone density, with a favorable trend at the femoral neck. Evidence for fracture outcomes was insufficient.

What this study can and cannot tell us

The included evidence was observational, not supplementation trials. Associations cannot establish that adding a magnesium supplement prevents osteoporosis or fractures.

Related papers in the corpus

Tier 1
Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials
Xi Zhang et al. · Hypertension (Dallas, Tex. : 1979) · 2016
Tier 1
Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Zoe Argeros et al. · Hypertension (Dallas, Tex. : 1979) · 2025
Tier 1
Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial
Kseniia Afitska et al. · Magnesium research · 2021
Tier 1
Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
Nicola Veronese et al. · Nutrients · 2021
Tier 1
A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control
Luis E Simental-Mendía et al. · Pharmacological research · 2016
Tier 1
Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial
Elizabeth Sun et al. · The American journal of clinical nutrition · 2025

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research