Tier 1 — highest

Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zoe Argeros, Xiaoye Xu, Buna Bhandari, Katie Harris, Rhian M Touyz, Aletta E Schutte
Hypertension (Dallas, Tex. : 1979) 2025 82(11):1844-1856

Bibliography

PubMed
PMID 41000008
PubMed Central
PMC12529988
DOI
10.1161/HYPERTENSIONAHA.125.25129
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The source discloses financial, employment, advisory or material-support relationships involving Roche. See the publication for the authors and nature of each relationship.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample38 randomized trials involving 2,709 adults
Intervention82.3–637 mg/day elemental magnesium; median 365 mg/day
DurationMedian 12 weeks
EndpointsSystolic and diastolic blood pressure; Dose-response and subgroup effects

What the study showed, in plain terms

This publication examines systolic and diastolic blood pressure, dose-response and subgroup effects. Study population or evidence base: 38 randomized trials involving 2,709 adults. Intervention or exposure: 82.3–637 mg/day elemental magnesium; median 365 mg/day.

Key findings

Magnesium lowered blood pressure modestly overall, with larger effects in hypertensive or magnesium-deficient groups. The normotensive subgroup did not show a significant effect.

What this study can and cannot tell us

High between-study heterogeneity and no clear dose-response relationship. The review overlaps earlier magnesium blood-pressure meta-analyses.

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