Tier 1 — highest

A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control

Luis E Simental-Mendía, Amirhossein Sahebkar, Martha Rodríguez-Morán, Fernando Guerrero-Romero
Pharmacological research 2016 111:272-282

Bibliography

PubMed
PMID 27329332
DOI
10.1016/j.phrs.2016.06.019
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample22 glucose, 14 HbA1c, 12 insulin and 10 HOMA-IR treatment-arm analyses
InterventionOral magnesium supplementation; formulations and doses varied
DurationVaried; analyses included interventions shorter and longer than 4 months
EndpointsGlucose; HbA1c; Insulin; HOMA-IR

What the study showed, in plain terms

This publication examines glucose, hba1c, insulin, homa-ir. Study population or evidence base: 22 glucose, 14 HbA1c, 12 insulin and 10 HOMA-IR treatment-arm analyses. Intervention or exposure: Oral magnesium supplementation; formulations and doses varied.

Key findings

Magnesium improved pooled HOMA-IR but not overall glucose, HbA1c or insulin. Longer-duration subgroups showed more favorable glucose and insulin-resistance findings.

What this study can and cannot tell us

Different numbers of trial arms contributed to each outcome. Subgroup duration findings and heterogeneous populations limit simple dosing conclusions.

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