Tier 1 — highest

Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women

Toshiyuki Yasui, Yuka Miyatani, Junko Tomita, Masayo Yamada, Hirokazu Uemura, Masakazu Miura, Minoru Irahara
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2006 22(8):455-9

Bibliography

PubMed
PMID 17012108
DOI
10.1080/09513590600900402
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample34 early postmenopausal women with low bone density
InterventionMK-4 45 mg/day, alone or with alfacalcidol 0.75 μg/day
Duration2 years
EndpointsOsteocalcin carboxylation; Bone-turnover markers; Lumbar bone density

What the study showed, in plain terms

This publication examines osteocalcin carboxylation, bone-turnover markers, lumbar bone density. Study population or evidence base: 34 early postmenopausal women with low bone density. Intervention or exposure: MK-4 45 mg/day, alone or with alfacalcidol 0.75 μg/day.

Key findings

Both regimens reduced undercarboxylated osteocalcin. Adding the active vitamin D analogue also changed selected bone-turnover markers.

What this study can and cannot tell us

Small active-treatment comparison without a placebo arm. Alfacalcidol and pharmacological-dose MK-4 should be distinguished from ordinary D3 and nutritional-dose MK-7.

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