Tier 1 — highest

Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial

Siyin Wu, Tian Jin, Bingjie Ma, Yun Ji, Xuehua Huang, Peiliang Wang, Xiaoming Liu, Boris V Krylov, Xianguo Liu, Ke Ma
Cancer medicine 2023 12(4):4343-4351

Bibliography

PubMed
PMID 36703238
PubMed Central
PMC9972038
DOI
10.1002/cam4.4922
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample83 patients with advanced cancer receiving opioids
InterventionMagnesium L-threonate 1.5–2 g/day according to weight, or placebo
Duration90 days
EndpointsIncrease in daily morphine requirement; Opioid-related constipation

What the study showed, in plain terms

This publication examines increase in daily morphine requirement, opioid-related constipation. Study population or evidence base: 83 patients with advanced cancer receiving opioids. Intervention or exposure: Magnesium L-threonate 1.5–2 g/day according to weight, or placebo.

Key findings

Patients receiving magnesium L-threonate required smaller increases in morphine dose from day 30 onward. The authors also reported less opioid-related constipation.

What this study can and cannot tell us

A small specialist pain-management trial alongside opioids. Results do not establish general pain relief, cancer treatment efficacy or benefits of a lower-dose retail combination.

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