Tier 3 — preclinical

Enhancement of learning and memory by elevating brain magnesium

Inna Slutsky, Nashat Abumaria, Long-Jun Wu, Chao Huang, Ling Zhang, Bo Li, Xiang Zhao, Arvind Govindarajan, Ming-Gao Zhao, Min Zhuo, Susumu Tonegawa, Guosong Liu
Neuron 2010 65(2):165-77

Bibliography

PubMed
PMID 20152124
DOI
10.1016/j.neuron.2009.12.026
Funding
Support is recorded from NINDS NIH HHS. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignPreclinical behavioral, electrophysiological and synaptic study
ModelYoung and aged rats, with laboratory neuronal analyses
SampleMultiple animal and laboratory experiments; no human clinical cohort
InterventionMagnesium L-threonate used to raise brain magnesium in rats
DurationExperimental exposure schedules varied
EndpointsLearning and memory tasks; Synaptic density; Synaptic plasticity

What the study showed, in plain terms

This publication examines learning and memory tasks, synaptic density, synaptic plasticity. Study population or evidence base: Multiple animal and laboratory experiments; no human clinical cohort. Intervention or exposure: Magnesium L-threonate used to raise brain magnesium in rats.

Key findings

Raising brain magnesium with magnesium L-threonate improved several learning and memory measures and altered synaptic structure and signaling in rats.

What this study can and cannot tell us

Foundational animal research provides biological plausibility. It does not establish human brain delivery, an effective human dose or prevention of dementia.

Related papers in the corpus

Tier 1
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
Guosong Liu et al. · Journal of Alzheimer's disease : JAD · 2016
Tier 1
A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
Chengxiang Zhang et al. · Nutrients · 2022
Tier 1
Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial
Heather A Hausenblas et al. · Sleep medicine: X · 2024
Tier 1
The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
Adrian L Lopresti et al. · Frontiers in nutrition · 2026
Tier 1
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial
Siyin Wu et al. · Cancer medicine · 2023
Tier 1
A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery
Yuncheng Ni et al. · Breast cancer (Dove Medical Press) · 2023

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research