Tier 1 — highest

A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery

Yuncheng Ni, Fang Deng, Shanzi Yu, Jianping Zhang, Xiaoxue Zhang, Dong Huang, Haocheng Zhou
Breast cancer (Dove Medical Press) 2023 15:495-504

Bibliography

PubMed
PMID 37520407
PubMed Central
PMC10386839
DOI
10.2147/BCTT.S413435
Funding
Funding or support is described in the linked original publication; the indexed record does not provide a concise sponsor attribution.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized, double-blind, placebo-controlled clinical trial
ModelHuman participants
Sample109 women undergoing breast cancer surgery
InterventionMagnesium L-threonate 1.2 g/day, providing 91.8 mg elemental magnesium, or placebo
Duration12-week supplementation; follow-up to 6 months
EndpointsPersistent postoperative pain; Pain severity; Mood; Sleep and cognition

What the study showed, in plain terms

This publication examines persistent postoperative pain, pain severity, mood, sleep and cognition. Study population or evidence base: 109 women undergoing breast cancer surgery. Intervention or exposure: Magnesium L-threonate 1.2 g/day, providing 91.8 mg elemental magnesium, or placebo.

Key findings

Magnesium L-threonate did not significantly prevent persistent pain or improve between-group pain, mood, sleep or cognitive outcomes in this surgical setting.

What this study can and cannot tell us

A condition-specific postoperative trial. The absence of benefit here does not resolve other magnesium indications, but it limits claims about this regimen for persistent surgical pain.

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