Tier 4 — mechanistic

Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II

Isis Trujillo-González, Giannella Barisione, Teodoro Bottiglieri, Marcela Reyes, María Luisa Garmendia, María F Mujica-Coopman
The Journal of nutrition 2026 156(8):101665

Bibliography

PubMed
PMID 42269933
DOI
10.1016/j.tjnut.2026.101665
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
Reported disclosure: The authors report no conflicts of interest.

Study snapshot

DesignProspective mother-child cohort
ModelHuman participants
Sample150 mother-child pairs
InterventionMeasured betaine status and related metabolites; no randomized TMG treatment
DurationPregnancy through age 2-3 years
EndpointsChild growth; Methylation potential

What the study showed, in plain terms

Published in 2026, this source examined human observational and biomarker research. It examined Measured betaine status and related metabolites; no randomized TMG treatment. The source describes 150 mother-child pairs.

Maternal betaine was not significantly associated with birth measurements but was associated with higher weight/adiposity measures later in childhood.

Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.

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Key findings

  • Maternal betaine was not significantly associated with birth measurements but was associated with higher weight/adiposity measures later in childhood.
  • The recorded outcome domains were Child growth; Methylation potential.

What this study can and cannot tell us

  • Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology