Tier 4 — mechanistic

Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients

Weibang Yu, Chuncao Xu, Guomin Li, Weipeng Hong, Ziyi Zhou, Canxing Xiao, Yuanqi Zhao, Yefeng Cai, Min Huang, Jing Jin
Journal of pharmaceutical and biomedical analysis 2018 152:179-187

Bibliography

PubMed
PMID 29414011
DOI
10.1016/j.jpba.2018.01.049
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignAnalytical validation with clinical application
ModelFood, milk or laboratory samples
Sample220 acute-stroke patients in the application sample
InterventionMeasured betaine status and related metabolites; no randomized TMG treatment
DurationPlasma assay and clinical-prognosis assessment
EndpointsPlasma assay; Stroke prognosis

What the study showed, in plain terms

Published in 2018, this source examined human observational and biomarker research. It examined Measured betaine status and related metabolites; no randomized TMG treatment. The source describes 220 acute-stroke patients in the application sample.

The assay quantified TMAO, choline and betaine; the main reported prognostic association concerned choline.

Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.

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Key findings

  • The assay quantified TMAO, choline and betaine; the main reported prognostic association concerned choline.
  • The recorded outcome domains were Plasma assay; Stroke prognosis.

What this study can and cannot tell us

  • Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies
Katie A Meyer et al. · Nutrients · 2017
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Dietary Choline and Betaine Are Not Associated With the Risk of Type 2 Diabetes. A Systematic Review and Meta-Analysis of Observational Studies
Elham Sharifi-Zahabi et al. · Journal of diabetes research · 2026
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Association of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis
Qinglin Yang et al. · European journal of clinical investigation · 2023
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Association of choline and betaine levels with cancer incidence and survival: A meta-analysis
Jiyoung Youn et al. · Clinical nutrition (Edinburgh, Scotland) · 2019

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology