Tier 2 — strong

Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy

Francien V Velzing-Aarts, Pål I Holm, M Rebecca Fokkema, Fey P van der Dijs, Per M Ueland, Frits A Muskiet
The American journal of clinical nutrition 2005 81(6):1383-1389

Bibliography

PubMed
PMID 15941891
DOI
10.1093/ajcn/81.6.1383
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignLongitudinal pregnancy study
ModelHuman participants
Sample50 women of West African descent
InterventionMeasured betaine status and related metabolites; no randomized TMG treatment
DurationMonthly pregnancy sampling through about 3 months postpartum
EndpointsPregnancy metabolism; Homocysteine

What the study showed, in plain terms

Published in 2005, this source examined human observational and biomarker research. Design: Longitudinal pregnancy study. Sample/model: 50 women of West African descent. The exposure or intervention was Measured betaine status and related metabolites; no randomized TMG treatment. Follow-up or treatment period: Monthly pregnancy sampling through about 3 months postpartum.

Betaine fell during early pregnancy and later became an important inverse predictor of homocysteine.

Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.

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Key findings

  • Betaine fell during early pregnancy and later became an important inverse predictor of homocysteine.
  • The recorded outcome domains were Pregnancy metabolism; Homocysteine.
  • The result applies to the tested exposure: Measured betaine status and related metabolites; no randomized TMG treatment; Monthly pregnancy sampling through about 3 months postpartum.

What this study can and cannot tell us

  • Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology