Tier 1 — highest

Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis

M Shiraki, Y Shiraki, C Aoki, M Miura
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000 15(3):515-21

Bibliography

PubMed
PMID 10750566
DOI
10.1359/jbmr.2000.15.3.515
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample241 people with osteoporosis
InterventionMK-4 45 mg/day versus an untreated control group
Duration24 months
EndpointsClinical fractures; Lumbar bone density; Osteocalcin carboxylation

What the study showed, in plain terms

This publication examines clinical fractures, lumbar bone density, osteocalcin carboxylation. Study population or evidence base: 241 people with osteoporosis. Intervention or exposure: MK-4 45 mg/day versus an untreated control group.

Key findings

The MK-4 group had fewer clinical fractures and better preservation of lumbar bone density than untreated controls.

What this study can and cannot tell us

This was an open-label trial using pharmacological-dose MK-4 and an untreated comparison. Its findings should not be transferred directly to nutritional-dose MK-7.

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