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Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials

Ming-Ling Ma, Zi-Jian Ma, Yi-Lang He, Hao Sun, Bin Yang, Bin-Jia Ruan, Wan-da Zhan, Shi-Xuan Li, Hui Dong, Yong-Xiang Wang
Frontiers in public health 2022 10:979649

Bibliography

PubMed
PMID 36033779
PubMed Central
PMC9403798
DOI
10.3389/fpubh.2022.979649
Funding
Support is recorded from Jiangsu provincial research programmes, Yangzhou research funding. See the original publication for grant and material-support details.
Competing interests
The publication includes author disclosures; consult the linked source for the individual relationships and their relevance.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample16 randomized trials involving 6,425 participants
InterventionDifferent K2 regimens, alone or with other osteoporosis treatments
DurationVaried across trials
EndpointsBone mineral density; Fracture incidence; Osteocalcin carboxylation; Adverse events

What the study showed, in plain terms

This publication examines bone mineral density, fracture incidence, osteocalcin carboxylation, adverse events. Study population or evidence base: 16 randomized trials involving 6,425 participants. Intervention or exposure: Different K2 regimens, alone or with other osteoporosis treatments.

Key findings

The pooled analysis favored K2 for lumbar spine density and osteocalcin measures. Fracture incidence was neutral overall and became favorable only after excluding a heterogeneous study.

What this study can and cannot tell us

Fracture conclusions were sensitive to study selection. Trials differed in K2 form, dose and co-treatment, limiting direct application to a particular MK-7 supplement.

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