Tier 1 — highest

Randomized Study of the Effects of Vitamin D and Magnesium Co-Supplementation on Muscle Strength and Function, Body Composition, and Inflammation in Vitamin D-Deficient Middle-Aged Women

Fatemeh Kheyruri, Javad Sarrafzadeh, Agha Fatemeh Hosseini, Behnaz Abiri, Mohammadreza Vafa
Biological trace element research 2021 199(7):2523-2534

Bibliography

PubMed
PMID 32955720
DOI
10.1007/s12011-020-02387-2
Funding
Support is recorded from Iran University of Medical Sciences. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample83 vitamin D-deficient women aged 40–55 randomized
Intervention50,000 IU vitamin D weekly plus 250 mg magnesium daily, versus matching placebos
Duration8 weeks
EndpointsGrip and knee-extension strength; Timed Get Up and Go; Body composition; Inflammatory markers

What the study showed, in plain terms

This publication examines grip and knee-extension strength, timed get up and go, body composition, inflammatory markers. Study population or evidence base: 83 vitamin D-deficient women aged 40–55 randomized. Intervention or exposure: 50,000 IU vitamin D weekly plus 250 mg magnesium daily, versus matching placebos.

Key findings

The intervention improved grip strength and timed mobility and reduced hs-CRP. Knee-extension strength, body composition and between-group TNF-α and IL-6 outcomes were not significantly improved.

What this study can and cannot tell us

Short-term results in vitamin D-deficient middle-aged women. Without single-nutrient arms, the separate contribution of magnesium cannot be determined.

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