Tier 1 — highest

Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms

Behnaz Abiri, Parvin Sarbakhsh, Mohammadreza Vafa
Nutritional neuroscience 2022 25(10):2123-2135

Bibliography

PubMed
PMID 34210242
DOI
10.1080/1028415X.2021.1945859
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample108 women with obesity and mild-to-moderate depressive symptoms; 27 per arm
Intervention50,000 IU vitamin D weekly, 250 mg magnesium daily, both, or double placebo
Duration8 weeks
EndpointsBDI-II depression score; BDNF; Inflammation; SIRT1

What the study showed, in plain terms

This publication examines bdi-ii depression score, bdnf, inflammation, sirt1. Study population or evidence base: 108 women with obesity and mild-to-moderate depressive symptoms; 27 per arm. Intervention or exposure: 50,000 IU vitamin D weekly, 250 mg magnesium daily, both, or double placebo.

Key findings

Several biochemical measures differed between groups, but depression scores improved in all four arms without a significant between-group difference. hs-CRP and SIRT1 also did not differ significantly.

What this study can and cannot tell us

The abstract's favorable conclusion should be read alongside its neutral between-group depression result. This short study does not establish treatment efficacy for depression.

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