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Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis

Wang J, Bi C, Xi H, Wei F
Frontiers in pharmacology 2024 15:1455534

Bibliography

PubMed
PMID 39640489
PubMed Central
PMC11617981
Funding
Supported by a Chinese traditional-medicine inheritance-studio program and the Shandong Natural Science Foundation.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample50 studies; 4150 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The review separated berberine-only and add-on regimens and found glycemic signals across several comparisons.

Key findings

  • The review separated berberine-only and add-on regimens and found glycemic signals across several comparisons.

What this study can and cannot tell us

Different comparators and background drugs cannot be pooled into a claim that berberine replaces prescribed diabetes treatment.

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