Tier 2 — strong

The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial

Nematollahi S, Pishdad GR, Zakerkish M, Namjoyan F, Ahmadi Angali K, Borazjani F
Diabetology & metabolic syndrome 2022 14(1):120

Bibliography

PubMed
PMID 35999562
PubMed Central
PMC9395822
DOI
10.1186/s13098-022-00888-9
Funding
Indexed support: Ahvaz Jundishapur University of Medical Sciences. See the publication for grant details.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignDouble-blind randomized combination trial
ModelHuman participants; see population
Sample50 adults with type 2 diabetes
InterventionThree daily capsules, each with berberine 300 mg and fenugreek 200 mg, versus placebo
Duration12 weeks
EndpointsFasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability

What the study showed, in plain terms

The combination produced selected glycemic and quality-of-life signals. Within-group HbA1c and inflammatory changes should be distinguished from between-group effects.

Key findings

  • The combination produced selected glycemic and quality-of-life signals. Within-group HbA1c and inflammatory changes should be distinguished from between-group effects.

What this study can and cannot tell us

No berberine-only or fenugreek-only arm; small sample and multiple outcomes.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology