Tier 2 — strong

Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial

León-Martínez JM, Martínez-Abundis E, González-Ortiz M, Pérez-Rubio KG
Journal of medicinal food 2021 24(2):111-115

Bibliography

PubMed
PMID 32397850
DOI
10.1089/jmf.2020.0029
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignDouble-blind three-arm randomized pilot
ModelHuman participants; see population
Sample36 adults; 12 per arm
InterventionBerberine 500 mg three times/day, bezafibrate 400 mg twice/day or combination
Duration90 days
EndpointsTotal and LDL cholesterol; Triglycerides and apolipoproteins; Metabolic and vascular biomarkers

What the study showed, in plain terms

The combination and bezafibrate arms improved several lipid measures in a small active-comparator pilot.

Key findings

  • The combination and bezafibrate arms improved several lipid measures in a small active-comparator pilot.

What this study can and cannot tell us

No placebo arm and very small treatment groups; within-arm declines do not demonstrate combination superiority.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology