Tier 2 — strong

Effects of a New Nutraceutical Formulation (Berberine, Red Yeast Rice and Chitosan) on Non-HDL Cholesterol Levels in Individuals with Dyslipidemia: Results from a Randomized, Double Blind, Placebo-Controlled Study

Spigoni V, Aldigeri R, Antonini M, Micheli MM, Fantuzzi F, Fratter A, Pellizzato M, Derlindati E, Zavaroni I, Bonadonna RC, Dei Cas A
International journal of molecular sciences 2017 18(7):E1498

Bibliography

PubMed
PMID 28704936
PubMed Central
PMC5535988
DOI
10.3390/ijms18071498
Funding
Doc Generici sponsored the study and publication fees.
Competing interests
Industry sponsorship by Doc Generici is disclosed; the full individual author declaration should be consulted.

Study snapshot

DesignDouble-blind placebo-controlled combination randomized trial
ModelHuman participants; see population
Sample39 adults randomized 3:1
InterventionCombination of berberine, monacolin K, chitosan and CoQ10 versus placebo
Duration12 weeks
EndpointsTotal and LDL cholesterol; Triglycerides and apolipoproteins; Metabolic and vascular biomarkers

What the study showed, in plain terms

A multi-ingredient preparation lowered non-HDL cholesterol, LDL and apoB.

Key findings

  • A multi-ingredient preparation lowered non-HDL cholesterol, LDL and apoB.

What this study can and cannot tell us

Monacolin K is pharmacologically active; the result cannot be assigned to berberine. Small unequal groups and an observed CK elevation warrant context.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology