Product Review

DoNotAge Pure Resveratrol Review

5/5 Editorial scoreBEST OVERALL

5.0/5 and our #1 overall Resveratrol pick for 2026. DoNotAge gets the fundamentals unusually right: 500 mg of 99% trans-resveratrol per capsule/scoop, a clean single-ingredient proposition, capsule and powder options,...

Trans-resveratrol

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By Dr. Khaled Mahmoud, MBBCh

Reviewed by Dr. Abdulla Mostafa, PhD, Dr. Amr Yasser, PhD

· 14 min read

How we scored it

Our editorial recommendation uses a 1–5 scale. We consider the formulation, label clarity, manufacturer quality disclosures, practical use and value for the intended reader. The published rating is an overall editorial judgment; these factors are not separately measured or weighted.

5/5 means a top editorial recommendation for the stated use case. It does not establish clinical effectiveness or mean that we performed laboratory testing. Research strength and safety limitations are assessed separately in this review.

5.0/5 overall within our 2026 Resveratrol product rubric: 500 mg of 99% trans-resveratrol per capsule/scoop, capsules or powder, simple formulation, strong testing disclosure, COA availability, practical dosing and excellent overall value. The score rates the finished product—not unproven lifespan or SIRT1 claims.

Read the review summary

Our definitive 2026 review of DoNotAge Pure Resveratrol, scored against Biohack Blueprint's 97-paper evidence database and real competing products for dose, trans-resveratrol purity, testing, formulation, bioavailability, safety and value.

5.0/5 and our #1 overall Resveratrol pick for 2026. DoNotAge gets the fundamentals unusually right: 500 mg of 99% trans-resveratrol per capsule/scoop, a clean single-ingredient proposition, capsule and powder options, stated every-batch quality testing with COA availability, and strong value. It is not automatically the best choice for someone prioritizing a proprietary enhanced-delivery system or 1 g bulk servings, but it is the strongest all-round product in our comparison. We rate the product separately from the broader resveratrol science, where lifespan extension and consistent human SIRT1 activation are not established.

Evidence for an ingredient does not establish the effects of this finished product. See the evidence section for study design, dose and limitations.

DoNotAge Pure Resveratrol supplement bottle View image

DoNotAge Pure Resveratrol supplement bottle

Read the full editorial assessment

DoNotAge Pure Resveratrol is our #1 overall Resveratrol supplement for 2026 and earns 5.0/5 within Biohack Blueprint's product-review rubric. The case is product-level, not hype-level: 500 mg per capsule or scoop, 99% trans-resveratrol, capsule and powder formats, a simple no-filler positioning, stated in-house and third-party testing, COA availability on request, and GMP/ISO9001 manufacturing claims. ProHealth offers a stronger bulk-dose proposition and Life Extension has the clearer enhanced-bioavailability technology; DoNotAge wins overall because it balances dose, active-form disclosure, format choice, formulation simplicity, testing transparency and value better than the field. None of that changes the molecule-level evidence: human lifespan extension and consistent systemic SIRT1 activation remain unproven.

Formulation strengths and limitations

Key takeaways

  • DoNotAge Pure Resveratrol earns 5.0/5 and our #1 overall 2026 ranking because it balances 500 mg dosing, 99% trans-resveratrol, format choice, formulation simplicity, testing transparency and value better than the products we compared.
  • 500 mg is a research-relevant dose used in modern human trials, but no universal optimal resveratrol dose has been established.
  • 99% trans-resveratrol purity tells you what is in the product; it does not mean 99% oral bioavailability. Rapid metabolism remains central to resveratrol pharmacology.
  • Medication review matters: controlled human studies show resveratrol can alter several CYP drug-metabolizing enzymes, and bleeding-risk combinations deserve caution.
Physician-reviewed 5.0/5 editorial rating #1 Resveratrol pick 97-paper Data Center 500 mg per capsule/scoop 99% trans-resveratrol In-house + third-party testing stated COA available on request GMP & ISO9001 stated BB10 saves 10%

Formulation

Key facts & composition

Active form Trans-resveratrol The form most commonly used in modern human supplementation studies.
Amount 500 mg per capsule/scoop Current manufacturer listing; no universal optimal resveratrol dose has been established.
Purity 99% trans-resveratrol Manufacturer-reported active-form purity; purity is not the same as bioavailability.
Source Primarily Japanese knotweed Manufacturer-reported botanical sourcing.
Formats Capsules and powder Useful choice for readers who prefer fixed-dose capsules or flexible powder measurement.
Testing In-house + third-party testing stated Manufacturer states every batch is tested and COAs are available on request; Biohack Blueprint has not independently assayed the current retail lot.

Composition

Ingredient Amount Form Source
Trans-resveratrol 500 mg per capsule/scoop 99% trans-resveratrol Primarily Japanese knotweed (manufacturer-reported)

DoNotAge currently lists 500 mg per capsule/scoop and a recommended daily serving of 500 mg near the top of the product page. Its FAQ also refers to a typical daily dosage of two capsules or 1 g powder, so readers should follow the current package directions or obtain individual clinical advice rather than treating website copy as a personalized dose.

Who this is for

Good fit if you're...

Readers who want a clearly disclosed trans-resveratrol dose

The label-level proposition is simple: 500 mg per capsule/scoop and 99% trans-resveratrol, without hiding the active amount inside a vague botanical blend.

People who prefer a simple single-ingredient formula

A straightforward formula makes it easier to evaluate dose, tolerance and interactions without multiple active ingredients confounding the picture.

People who value capsule or powder choice

DoNotAge currently offers both formats, which can suit fixed-dose convenience or users who prefer measuring powder.

Probably not for you if...

People taking interacting prescription medication without professional review

Human CYP interaction evidence means prescription-drug users should have the combination reviewed rather than treating concentrated resveratrol as metabolically inert.

Anyone looking for a proven human lifespan-extending intervention

Resveratrol has not been shown to extend human lifespan. The longevity story remains mainly mechanistic and preclinical.

Anyone assuming 99% purity means 99% bioavailability

Purity and pharmacokinetics are different. Oral resveratrol is substantially absorbed but rapidly metabolized, leaving low free parent-compound exposure.

How it works

Resveratrol influences several pathways relevant to aging biology, including SIRT1-related signaling, AMPK/PGC-1α, mitochondrial regulation, endothelial function and inflammatory signaling. The pathway evidence is much stronger than the evidence for lifespan extension. The sections below separate mechanistic plausibility from human clinical outcomes.

1

SIRT1 and energy-sensing biology

Resveratrol is deeply linked to SIRT1, AMPK and calorie-restriction research. Preclinical evidence is strong enough to make the pathway biologically important, but the best pooled human evidence does not show a significant overall increase in SIRT1 gene expression, protein expression or circulating SIRT1. Treat SIRT1 as a mechanism under study, not a clinically proven longevity switch.

2

AMPK, PGC-1α and mitochondrial signaling

Small human trials have reported changes in skeletal-muscle AMPK/ACC phosphorylation, PGC-1α and mitochondrial endpoints. Other randomized studies are null. These pathway-level findings support biological activity, but they do not establish that a retail resveratrol product improves lifespan or broad metabolic health.

3

Oxidative, inflammatory and vascular signaling

Meta-analyses report modest improvements in selected inflammatory, blood-pressure and lipid biomarkers in some populations. Those are surrogate outcomes. They are not equivalent to preventing cardiovascular disease, reversing aging or extending lifespan.

Research & evidence

20 cited sources · Resveratrol Data Center

The evidence

Sources include research papers and other cited records, such as registered trials. A trial registration is not a published result.

Claims are graded from A to D by the strength, consistency and human relevance of the evidence—not by how attractive the mechanism sounds. Product quality and molecule-level efficacy are evaluated separately.

B Resveratrol can modestly improve selected cardiometabolic biomarkers in some populations Tier 1

Recent meta-analytic and umbrella-level evidence supports modest, context-dependent improvements in selected outcomes such as blood pressure, insulin resistance, lipids and inflammatory markers. Effects are heterogeneous and should not be generalized to every population or endpoint.

Jia-Nan Sun et al. 2026 , Chun-Yu Shen et al. 2026 , Faezeh Ghalichi et al. 2026

D Oral resveratrol consistently activates SIRT1 in humans Tier 1

A 2025 GRADE-assessed meta-analysis of 11 randomized trials found no significant overall increase in SIRT1 gene expression, protein expression or circulating SIRT1. Individual positive studies exist, but they do not support a blanket systemic-activation claim.

Fatemeh Mansouri et al. 2025 , Asima Karim et al. 2025

A Oral resveratrol is absorbed but rapidly metabolized, leaving low free parent-resveratrol exposure Tier 1

Classic radiolabeled human work showed substantial absorption with only trace unchanged resveratrol in plasma, and later dose-escalation, repeated-dose and meta-analytic pharmacokinetic evidence confirms extensive metabolism and high between-study variability.

Thomas Walle et al. 2004 , David J Boocock et al. 2007 , Luis Almeida et al. 2009 , Izabela Szymkowiak et al. 2025

D Resveratrol reliably causes clinically meaningful weight loss Tier 1

Large recent synthesis does not show consistent reductions in body weight, BMI, fat mass or waist/hip circumference. Metabolic pathway effects should not be converted into a weight-loss claim.

Chun-Yu Shen et al. 2026 , Poulsen MM et al. 2013

D Resveratrol extends human lifespan Tier 4

The longevity reputation is driven largely by mechanistic and animal research, including landmark high-calorie-diet mouse work. No randomized human trial demonstrates lifespan extension from resveratrol supplementation.

Baur JA et al. 2006 , Jia-Nan Sun et al. 2026

D DoNotAge Pure Resveratrol has proven superior clinical efficacy to other resveratrol products Tier 3

The product has clear label-level strengths—500 mg per capsule/scoop, 99% trans-resveratrol and stated testing—but no finished-product randomized trial establishes better clinical outcomes than competing resveratrol formulations. Product quality and clinical superiority are separate questions.

Karen Brown et al. 2024 , Izabela Szymkowiak et al. 2025

Scientific evidence rechecked 16 October 2026 against Biohack Blueprint's 97-paper Resveratrol Data Center and 20 directly cited research records. Current DoNotAge product specifications, testing statements and COA availability were rechecked against the manufacturer's live product information; Biohack Blueprint has not independently assayed the current retail lot.

Comparison

How it compares

DoNotAge Pure Resveratrol SupplementProHealth Pure Trans-Resveratrol Life Extension Resveratrol Elite
Trans-resveratrol per serving 500 mg; 99% trans-resveratrol 1,000 mg; ≥98% trans-resveratrol (Veri-te®) 30 mg trans-resveratrol in hydrogel blend
Available format Capsules or powder Powder Vegetarian capsules
Formulation approach High-purity single-ingredient resveratrol; no unnecessary fillers stated Micronized trans-resveratrol powder Fenugreek-galactomannan hydrogel delivery system
Testing transparency In-house + third-party testing stated; COA available on request Every-batch third-party testing stated; COA available Established manufacturer quality controls; no batch-COA claim relied on here
Bioavailability strategy Conventional high-purity trans-resveratrol; no proprietary delivery system Micronized powder Hydrogel system with human PK evidence of up to 10× exposure vs unformulated resveratrol
Best fit Best overall: high purity, 500 mg, capsules or powder, clean formulation Best for bulk high-dose micronized powder Best for enhanced-delivery / lower-dose PK technology

Clinical pharmacology

DoNotAge currently lists 500 mg of resveratrol per capsule or scoop. That sits inside a common modern human-trial range, but no single dose has been established as optimal for all outcomes. The current manufacturer page also contains inconsistent daily-use language—500 mg near the top versus two capsules or 1 g powder in the FAQ—so this review does not convert manufacturer website copy into personalized dosing advice.

Human pharmacokinetic evidence shows that oral resveratrol can be substantially absorbed while unchanged parent resveratrol remains low in circulation because of rapid sulfate and glucuronide metabolism. A 2025 meta-analysis across 84 oral administrations found dose-related increases in free resveratrol exposure but substantial methodological heterogeneity. Purity, dose and bioavailability are therefore different questions.

Dose tiers

TierDoseFrequencyDurationNotes
Lower-dose research territory 75–150 mg/day Daily Weeks to months in selected trials

Used in vascular, metabolic and cognition-related research. Positive and null findings both exist; this range should not be treated as a universal therapeutic dose.
Common modern trial dose 500 mg/day Daily Often 8–16 weeks

500 mg/day appears in several modern randomized trials, including cognition and osteoarthritis research. It is research-relevant, not proven optimal.
Higher-dose research 1,000–1,500 mg/day Daily Usually short-term

Used in metabolic, interaction and liver-related research. Higher exposure does not reliably mean better outcomes, and interaction/tolerability concerns become more relevant.
PK / safety research only 2,500–5,000 mg/day Daily Short pharmacokinetic or safety studies

Multi-gram doses help define pharmacokinetics and tolerability but are not sensible default consumer targets. Gastrointestinal adverse effects become increasingly relevant.

From bench to bedside

PathwayPreclinical findingHuman translationConfidence
SIRT1 / energy sensing Resveratrol influences sirtuin-related biology and has produced calorie-restriction-like effects in several experimental systems, including landmark mouse research. Individual human trials report SIRT1-related changes, but pooled randomized evidence does not show a significant overall increase in SIRT1 gene expression, protein expression or circulating SIRT1. Mixed
AMPK / PGC-1α / mitochondrial signaling Experimental models consistently connect resveratrol with cellular energy sensing, mitochondrial regulation and stress-response pathways. Selected human muscle and metabolic trials show pathway-level changes, while other well-controlled trials are null. Target engagement is plausible but not a universal clinical effect. Moderate
Endothelial and nitric-oxide signaling Resveratrol can influence vascular signaling, oxidative stress and nitric-oxide pathways in experimental models. Some human trials and pooled analyses show modest blood-pressure or endothelial-function signals, but hard cardiovascular event reduction has not been demonstrated. Moderate

Drug interactions

Moderate to potentially high

CYP-metabolized medicines

At 1 g/day for four weeks, human research found inhibition of CYP3A4, CYP2D6 and CYP2C9 and increased CYP1A2 activity; other human work supports a CYP2E1 interaction signal.

Recommendation:

Ask a clinician or pharmacist to review concentrated resveratrol if you use prescription medicines—especially drugs with a narrow therapeutic index or strong dependence on affected CYP pathways. Simply separating doses by a few hours may not remove enzyme-mediated interaction risk.

Caution

Anticoagulants / antiplatelet therapy

Resveratrol influences platelet-related biology in experimental research. The exact clinical bleeding-risk increment at ordinary supplement doses is not well quantified.

Recommendation:

Discuss use before combining concentrated resveratrol with anticoagulants, aspirin, clopidogrel or multiple agents that increase bleeding risk, and disclose use before surgery or invasive procedures.

Monitor

Glucose- or blood-pressure-lowering medicines

Some pooled human evidence shows modest glucose-related or blood-pressure effects, creating a plausible possibility of additive effects in medicated users.

Recommendation:

Do not reduce prescribed medication because you start resveratrol. Monitor clinically relevant symptoms or measurements and discuss changes with the prescribing clinician.

Bioavailability tips

Do not confuse 99% trans-resveratrol purity with 99% oral bioavailability. Human studies show high absorption can coexist with very low unchanged parent-resveratrol exposure because first-pass metabolism is rapid. Specific delivery technologies can change Cmax or AUC, but a pharmacokinetic advantage does not automatically establish superior clinical outcomes. There is also no universal human-outcome rule requiring a high-fat meal; taking resveratrol with food may still be practical if it improves gastrointestinal tolerance.

Special populations

PopulationRecommendationRationale
Pregnancy and breastfeeding Avoid unsupervised concentrated supplementation

Supplement-level resveratrol exposure has not been adequately established as safe during pregnancy or breastfeeding.
People preparing for surgery or using anticoagulant/antiplatelet therapy Clinician review recommended

Potential platelet effects and drug-interaction biology make perioperative or bleeding-risk contexts more important than routine supplement use in otherwise healthy adults.
Liver/kidney disease or polypharmacy Clinician or pharmacist review recommended

Human CYP interaction evidence and limited long-term high-risk-population data make individualized medication and disease-context review appropriate.

Therapeutic positioning

Resveratrol sits between mechanistically compelling longevity biology and mixed human clinical evidence. The useful comparison is not simply product versus product; it is also resveratrol versus stronger foundational interventions and versus alternative longevity-supplement strategies.

Exercise, diet, sleep and risk-factor treatment

Foundational health interventions Foundation first

These interventions have far stronger evidence for meaningful health outcomes than resveratrol supplementation. Resveratrol should sit on top of, not replace, evidence-based lifestyle and medical care.

NMN / NAD+ precursor strategy

Different longevity-supplement pathway Different mechanism

NMN and resveratrol are not interchangeable. NMN is studied primarily as an NAD+ precursor; resveratrol is a polyphenol with different pharmacokinetics and pathway biology. Combination theories should not be presented as proven superiority without human comparative data.

Enhanced-delivery resveratrol

Formulation alternative PK advantage may exist; outcomes unproven

Specific formulations can materially increase peak or total resveratrol exposure. That is a valid pharmacokinetic advantage when demonstrated for the exact formulation, but higher Cmax or AUC is not automatically proof of better clinical outcomes.

Red wine

Dietary source Not a supplement substitute

Wine contains far less resveratrol than many supplement trials and introduces alcohol-related risk. It is not a rational way to reproduce research doses.

Regular physical activity, sufficient sleep, diet quality, smoking avoidance, weight management and evidence-based treatment of blood pressure, lipids and diabetes have far stronger clinical-outcome evidence than resveratrol supplementation. Resveratrol can be an optional supplement layer; it should not replace those foundations.

This supplement is not a replacement for medical treatment, a balanced diet, regular exercise or individualized medical advice, and it should not be used to diagnose, treat, cure or prevent disease.

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About buying through us

Why is DoNotAge Pure Resveratrol your #1 overall pick?

Because it gives the strongest complete all-round package in our comparison: a 500 mg unit dose, a stated 99% trans-resveratrol specification, capsule and powder formats, a simple formulation, stated in-house and independent third-party testing, COA availability on request, and strong value. ProHealth has a stronger bulk-dose proposition and Life Extension has the clearer enhanced-delivery technology, but DoNotAge balances the most important finished-product criteria best overall.

Why choose DoNotAge over ProHealth or Life Extension?

The answer depends on what you prioritize. ProHealth is attractive if you specifically want a micronized bulk powder and larger serving flexibility. Life Extension is stronger if a proprietary enhanced-bioavailability system is your first priority. DoNotAge remains our #1 overall pick because it combines high disclosed trans-resveratrol purity, a practical 500 mg unit dose, capsule-or-powder choice, formulation simplicity, testing disclosure and value without asking the buyer to pay primarily for a delivery technology whose clinical-outcome advantage is still unproven.

Has the exact DoNotAge Pure Resveratrol product been clinically tested?

This review does not identify a randomized human trial of the exact finished DoNotAge Pure Resveratrol product. The clinical evidence section evaluates the resveratrol molecule and related formulations used in human research, while the 5/5 product score evaluates the finished product's disclosed dose, active form, formulation, testing, format choice and value. We keep those two evidence layers separate so product quality is not mistaken for product-specific efficacy proof.

Why not choose a liposomal or enhanced-bioavailability resveratrol instead?

That can be the better choice if maximizing measured plasma exposure is your main goal. Some delivery systems have human pharmacokinetic data showing higher exposure than unformulated resveratrol. We still rank DoNotAge #1 overall because our rubric also weighs active-form disclosure, useful unit dose, formulation simplicity, format choice, testing transparency and value. Higher bioavailability has not been shown to guarantee better longevity or other clinically meaningful outcomes.

Is a COA available for DoNotAge Pure Resveratrol?

DoNotAge states that certificates of analysis are available on request and that every batch is tested in-house and by independent third-party laboratories. We count that as a product-quality positive, while distinguishing it from having a public lot-specific report permanently visible online. Biohack Blueprint has not independently assayed the current retail lot.

Can I take DoNotAge Pure Resveratrol with prescription medication?

Do not assume that concentrated resveratrol is interaction-free. A controlled human study using 1 g/day for four weeks altered several CYP drug-metabolizing enzyme activities, including CYP3A4, CYP2D6, CYP2C9 and CYP1A2, and resveratrol also has plausible antiplatelet effects. If you take prescription medicines, anticoagulants or antiplatelet drugs, or are preparing for surgery, review the supplement with a clinician or pharmacist before use.

Reader questions

Is DoNotAge Pure Resveratrol worth it?

Yes—for readers who specifically want a high-strength, clearly disclosed trans-resveratrol product. It is our #1 overall Resveratrol pick for 2026 and earns 5.0/5 because DoNotAge combines a 500 mg unit dose, a stated 99% trans-resveratrol specification, capsule and powder formats, a simple formulation, stated in-house and third-party testing, COA availability on request, and strong overall value. The 5/5 rating scores the finished product; it does not mean resveratrol has been proven to extend human lifespan.

How much trans-resveratrol is in DoNotAge Pure Resveratrol?

DoNotAge currently lists 500 mg of resveratrol per capsule or scoop and states a 99% trans-resveratrol specification. That active-form disclosure matters because trans-resveratrol is the form most commonly discussed in human supplementation research. We keep the manufacturer-stated purity separate from questions of absorption and clinical effectiveness.

What is the right DoNotAge Resveratrol dose: 500 mg or 1 g?

The unit dose is clear: each capsule or scoop provides 500 mg. DoNotAge's current website presents more than one daily-use example, including 500 mg in its main serving information and 1 g in FAQ-style guidance. Human resveratrol trials also use widely different doses, so there is no universally established anti-aging dose. Follow the current product directions and individualized medical advice rather than copying a research dose from a study.

Is DoNotAge Pure Resveratrol third-party tested?

DoNotAge currently states that every batch is tested in-house and by independent third-party laboratories and that certificates of analysis are available on request. We treat those as manufacturer-reported quality controls. Biohack Blueprint has not independently assayed the current retail lot, so we do not present the testing statement as our own laboratory verification.

Does 99% trans-resveratrol purity mean 99% bioavailability?

No. Purity describes how much of the ingredient is the stated trans-resveratrol form; bioavailability describes what happens after you swallow it. Human pharmacokinetic studies show that oral resveratrol can be absorbed substantially while unchanged parent resveratrol remains low in circulation because it is rapidly converted to sulfate and glucuronide metabolites.

Should I take DoNotAge Resveratrol with food or fat?

DoNotAge's current guidance recommends taking resveratrol with a source of fat. Human outcome evidence has not established a universal rule that a high-fat meal makes ordinary resveratrol clinically more effective. Following the current product directions is reasonable, and taking it with food may also be useful if it improves gastrointestinal tolerance.

Is DoNotAge Pure Resveratrol safe?

Short-term human studies generally suggest that moderate resveratrol doses are tolerated, while gastrointestinal adverse effects become more common at higher gram-level intakes. Concentrated resveratrol can also affect drug-metabolizing enzymes and may matter in bleeding-risk or perioperative settings. If you use prescription medicines, anticoagulants or antiplatelet drugs, are preparing for surgery, are pregnant or breastfeeding, or have a significant medical condition, review supplementation with a clinician or pharmacist.

Does BB10 work on DoNotAge Pure Resveratrol?

Yes. Under Biohack Blueprint's current DoNotAge partnership terms, BB10 gives 10% off eligible standalone DoNotAge products, including Pure Resveratrol. Promotions and exclusions can change, so our DoNotAge discount-code page is the canonical place to verify the current terms before checkout.

Editorial credibility

Portrait of Dr. Khaled Mahmoud, ICU physician and founder of Biohack Blueprint

Author

Dr. Khaled Mahmoud, MBBCh

MBBCh

Critical Care Medicine, Longevity Science & Editorial Direction

Portrait of Dr. Abdulla Mostafa, neuroscience reviewer for Biohack Blueprint

Reviewer

Dr. Abdulla Mostafa, PhD

MBBCh, PhD, Neuroscience, Neurosurgery

Cellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology

Portrait of Dr. Amr Yasser, cardiometabolic and musculoskeletal reviewer for Biohack Blueprint

Reviewer

Dr. Amr Yasser, PhD

MBBCh, PhD, General Surgery, Cardiometabolic Medicine, Musculoskeletal Research

Cardiometabolic, Musculoskeletal, Gut & Bioavailability

5.0/5 overall within our 2026 Resveratrol product rubric: 500 mg of 99% trans-resveratrol per capsule/scoop, capsules or powder, simple formulation, strong testing disclosure, COA availability, practical dosing and excellent overall value. The score rates the finished product—not unproven lifespan or SIRT1 claims.

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  1. Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials Jia-Nan Sun, Rui Yang, Li Fang, Yun-Jia Li, Wei-Yi Xing, Ming-Li Sun, Lang Wu, Qi-Jun Wu, Ting-Ting Gong (2026) . Nutrition Journal Read on our Data CenterView on PubMed View on PMC DOI
  2. Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities Karen Brown, Despoina Theofanous, Robert G Britton, Grandezza Aburido, Coral Pepper, Shanthi Sri Undru, Lynne Howells (2024) . International Journal of Molecular Sciences Read on our Data CenterView on PubMed View on PMC DOI
  3. Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases Chun-Yu Shen, Chen-Pi Li, Jui-Ting Yu, Ying-Jui Ho, Ru-Yin Tsai (2026) . In Vivo Read on our Data CenterView on PubMed View on PMC DOI
  4. The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis Faezeh Ghalichi, Roghayeh Molani-Gol, Faezeh Tejareh, Laleh Payahoo (2026) . DARU Journal of Pharmaceutical Sciences Read on our Data CenterView on PubMed DOI
  5. Impact of Resveratrol Supplementation on Human Sirtuin 1: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of RCTs Fatemeh Mansouri, Giulia Feliziani, Laura Bordoni, Rosita Gabbianelli (2025) . Journal of the Academy of Nutrition and Dietetics Read on our Data CenterView on PubMed DOI
  6. High absorption but very low bioavailability of oral resveratrol in humans Thomas Walle, Faye Hsieh, Mark H DeLegge, John E Oatis Jr, U Kristina Walle (2004) . Drug Metabolism and Disposition Read on our Data CenterView on PubMed DOI
  7. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent David J Boocock, Guy E S Faust, Ketan R Patel, Anna M Schinas, Victoria A Brown, Murray P Ducharme, Tristan D Booth, James A Crowell, Marjorie Perloff, Andreas J Gescher, William P Steward, Dean E Brenner (2007) . Cancer Epidemiology, Biomarkers & Prevention Read on our Data CenterView on PubMed DOI
  8. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers Luis Almeida, Manuel Vaz-da-Silva, Amílcar Falcão, Eva Soares, Raquel Costa, Ana I Loureiro, Carlos Fernandes-Lopes, José-Francisco Rocha, Teresa Nunes, Lyndon Wright, Patrício Soares-da-Silva (2009) . Molecular Nutrition & Food Research Read on our Data CenterView on PubMed DOI
  9. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis Victoria A Brown, Ketan R Patel, Maria Viskaduraki, James A Crowell, Marjorie Perloff, Tristan D Booth, Grygoriy Vasilinin, Ananda Sen, Anna Maria Schinas, Gianfranca Piccirilli, Karen Brown, William P Steward, Andreas J Gescher, Dean E Brenner (2010) . Cancer Research Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  10. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study Hsiao-Hui Sherry Chow, Lianqin L Garland, Chiu-Hsieh Hsu, Dalia R Vining, Wendy M Chew, Joseph A Miller, Marjorie Perloff, James A Crowell, David S Alberts (2010) . Cancer Prevention Research Read on our Data CenterView on PubMed View on PMC DOI
  11. Resveratrol Bioavailability After Oral Administration: A Meta-Analysis of Clinical Trial Data Izabela Szymkowiak, Justyna Marcinkowska, Malgorzata Kucinska, Milosz Regulski, Marek Murias (2025) . Phytotherapy Research Read on our Data CenterView on PubMed DOI
  12. The effects of 12-weeks resveratrol supplementation on cognition, gastrointestinal microbiota, and systemic inflammation, in an overweight and obese human population: a randomized, double-blind, placebo controlled, parallel groups trial Emma Wightman, John Lodge, David Kennedy, Samantha Bowerbank, William Cheung, Lewis Cuthbertson, Andrew Nelson, Darren Smith (2026) . Frontiers in Nutrition Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  13. Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL) Christelle Nguyen, Emmanuel Coudeyre, Isabelle Boutron, Gabriel Baron, Camille Daste, Marie-Martine Lefèvre-Colau, Jérémie Sellam, Jennifer Zauderer, Francis Berenbaum, François Rannou (2024) . PLoS Medicine Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  14. Resveratrol treatment increases sirtuin 1 levels and alleviates frailty phenotype in knee osteoarthritis patients: a randomised placebo-controlled clinical trial Asima Karim, Haroon Ahmed Khan, Firdos Ahmad, Rizwan Qaisar (2025) . International Journal of Food Sciences and Nutrition Read on our Data CenterView on PubMed DOI
  15. Resveratrol improves health and survival of mice on a high-calorie diet Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) . Nature Read on our Data CenterView on PubMed View on PMC DOI
  16. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MKC, Kunz I, Schrauwen-Hinderling VB, Blaak E, Auwerx J, Schrauwen P (2011) . Cell Metabolism Read on our Data CenterView on PubMed View on PMC DOI
  17. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition Poulsen MM, Vestergaard PF, Clasen BF, Radko Y, Christensen LP, Stodkilde-Jorgensen H, Moller N, Jessen N, Pedersen SB, Jorgensen JOL (2013) . Diabetes Read on our Data CenterView on PubMed View on PMC DOI
  18. Supplementation with resveratrol modified gut microbiota improving insulin sensitivity and lipid metabolism in subjects with obesity and insulin resistance Martha Guevara-Cruz, Mónica Sánchez-Tapia, Laura A Velazquez-Villegas, Ivan Torre-Villalvazo, Rocio Guizar-Heredia, Einar Godínez-Salas, Adriana López-Barradas, Omar Granados, Gonzálo Torres-Villalobos, Nimbe Torres, Armando R Tovar (2025) . European Journal of Nutrition Read on our Data CenterView on PubMed DOI Clinical Trial
  19. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men Lasse Gliemann, Jakob Friis Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard, Ylva Hellsten (2013) . Journal of Physiology Read on our Data CenterView on PubMed View on PMC DOI
  20. Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women Stephen E Alway, Jean L McCrory, Kalen Kearcher, Austen Vickers, Benjamin Frear, Diana L Gilleland, Daniel E Bonner, James M Thomas, David A Donley, Mathew W Lively, Junaith S Mohamed (2017) . Journals of Gerontology Series A Read on our Data CenterView on PubMed View on PMC DOI
  • 17 Oct 2026 Updated the 2026 review with refreshed product specifications, competitor comparison, FAQ coverage, safety guidance, evidence grading and research references.
First published 16 Oct 2026 · Last verified 16 Oct 2026