The evidence base for resveratrol

Resveratrol is a stilbene polyphenol studied across cardiometabolic health, inflammation, body composition, renal biomarkers, cognition, menopause and longevity-related mechanisms. Supplements typically focus on trans-resveratrol, the trans isomer used in much of the clinical literature. The evidence is broad but uneven. Human randomized trials and meta-analyses support some outcome-specific signals, yet the strongest 2026 umbrella evidence is limited to a small number of context-specific associations. Mechanistic stories around SIRT1, calorie-restriction mimicry and lifespan extension are substantially stronger in preclinical research than in direct human outcome data. This Data Center separates human efficacy evidence from pharmacokinetics, safety, interaction studies and preclinical longevity research so each Biohack Blueprint article can trace claims back to the correct evidence layer.