Tier 1 — highest

The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial

S R Zwakenberg, P A de Jong, J W Bartstra, R van Asperen, J Westerink, H de Valk, R H J A Slart, G Luurtsema, J M Wolterink, G J de Borst, J A van Herwaarden, M A van de Ree, L J Schurgers, Y T van der Schouw, J W J Beulens
The American journal of clinical nutrition 2019 110(4):883-890

Bibliography

PubMed
PMID 31387121
PubMed Central
PMC6766434
DOI
10.1093/ajcn/nqz147
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from Dutch Heart Foundation. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample68 adults with type 2 diabetes and cardiovascular disease randomized
InterventionMK-7 360 μg/day or placebo
Duration6 months
EndpointsPET measures of active arterial calcification; CT calcification mass; dp-ucMGP

What the study showed, in plain terms

This publication examines pet measures of active arterial calcification, ct calcification mass, dp-ucmgp. Study population or evidence base: 68 adults with type 2 diabetes and cardiovascular disease randomized. Intervention or exposure: MK-7 360 μg/day or placebo.

Key findings

MK-7 improved dp-ucMGP but did not significantly improve CT calcification. PET activity tended to increase, a finding whose clinical interpretation was uncertain.

What this study can and cannot tell us

A small, short trial using an emerging imaging marker. The systemic-calcification and bone-density report is a secondary analysis of the same trial.

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