Tier 1 — highest

Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial

Nuanjanthip Naiyarakseree, Jeerath Phannajit, Wichai Naiyarakseree, Nanta Mahatanan, Pagaporn Asavapujanamanee, Sookruetai Lekhyananda, Supat Vanichakarn, Yingyos Avihingsanon, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
Nutrients 2023 15(11):2422

Bibliography

PubMed
PMID 37299386
PubMed Central
PMC10255064
DOI
10.3390/nu15112422
Funding
Support is recorded from Chulalongkorn University research funds, Kidney Foundation of Thailand, Pharma Nord, Ratchadapisek Somphoch Fund, Faculty of Medicine, Chulalongkorn University, The Kidney Foundation of Thailand, Research Unit for Metabolic Bone Disease in CKD patients, Faculty of Medicine, Chulalongkorn University. See the original publication for grant and material-support details.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample96 hemodialysis patients with arterial stiffness
InterventionMK-7 375 μg/day versus standard care
Duration24 weeks
EndpointsPulse-wave velocity; Arterial stiffness progression

What the study showed, in plain terms

This publication examines pulse-wave velocity, arterial stiffness progression. Study population or evidence base: 96 hemodialysis patients with arterial stiffness. Intervention or exposure: MK-7 375 μg/day versus standard care.

Key findings

The overall between-group change in arterial stiffness was not significant. A diabetes subgroup showed a favorable signal that requires confirmation.

What this study can and cannot tell us

Open-label design, a specialist dialysis population and subgroup analysis limit generalization. The overall primary result should be distinguished from subgroup findings.

Related papers in the corpus

Tier 1
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial
Marjo H J Knapen et al. · Thrombosis and haemostasis · 2015
Tier 1
Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial
Liv M Vossen et al. · JAMA cardiology · 2026
Tier 1
Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women
Femke de Vries et al. · Nutrients · 2025
Tier 1
The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial
S R Zwakenberg et al. · The American journal of clinical nutrition · 2019
Tier 1
Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
Jonas W Bartstra et al. · European journal of nutrition · 2021
Tier 1
Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial
Miles D Witham et al. · Journal of the American Society of Nephrology : JASN · 2020

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research