Tier 1 — highest

Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2

Jonas W Bartstra, Fieke Draaisma, Sabine R Zwakenberg, Nikolas Lessmann, Jelmer M Wolterink, Yvonne T van der Schouw, Pim A de Jong, Joline W J Beulens
European journal of nutrition 2021 60(3):1691-1699

Bibliography

PubMed
PMID 33068157
PubMed Central
PMC7987615
DOI
10.1007/s00394-020-02412-z
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from Dutch Heart Foundation, Hartstichting. See the original publication for grant and material-support details.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignSecondary analysis of a randomized placebo-controlled trial
ModelHuman participants
Sample68 randomized participants with type 2 diabetes and cardiovascular disease
InterventionVitamin K2 360 μg/day or placebo
Duration6 months
EndpointsSystemic arterial calcification; Vertebral bone density

What the study showed, in plain terms

This publication examines systemic arterial calcification, vertebral bone density. Study population or evidence base: 68 randomized participants with type 2 diabetes and cardiovascular disease. Intervention or exposure: Vitamin K2 360 μg/day or placebo.

Key findings

Vitamin K2 did not significantly slow progression of systemic arterial calcification or decline in vertebral bone density over six months.

What this study can and cannot tell us

This is a secondary report from NCT02839044, not a separate trial. Short follow-up and baseline calcification differences limit interpretation.

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