Tier 1 — highest

Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women

Femke de Vries, Rudolf Bittner, Katarzyna Maresz, François Machuron, Olav Gåserød, Jean-François Jeanne, Leon J Schurgers
Nutrients 2025 17(5):815

Bibliography

PubMed
PMID 40077685
PubMed Central
PMC11901762
DOI
10.3390/nu17050815
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from Gnosis by Lesaffre. See the original publication for grant and material-support details.
Competing interests
The source discloses financial, employment, advisory or material-support relationships involving Gnosis. See the publication for the authors and nature of each relationship.

Study snapshot

DesignPost hoc analysis of a randomized clinical intervention
ModelHuman participants
Sample165 women with low vitamin K status
InterventionMK-7 180 μg/day or placebo
Duration1 year
EndpointsVascular stiffness; Blood pressure; dp-ucMGP

What the study showed, in plain terms

This publication examines vascular stiffness, blood pressure, dp-ucmgp. Study population or evidence base: 165 women with low vitamin K status. Intervention or exposure: MK-7 180 μg/day or placebo.

Key findings

MK-7 improved vitamin K status. Post hoc analyses suggested less worsening of vascular stiffness after menopause, with additional signals among women with higher initial stiffness.

What this study can and cannot tell us

Menopause and stiffness subgroup analyses were post hoc. The study did not measure prevention of cardiovascular events.

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