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Assessment of bioavailability of Mg from Mg citrate and Mg oxide by measuring urinary excretion in Mg-saturated subjects

Tanja Werner, Martin Kolisek, Jürgen Vormann, Ivana Pilchova, Marian Grendar, Eva Struharnanska, Michal Cibulka
Magnesium research 2019 32(3):63-71

Bibliography

PubMed
PMID 32162607
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignComparative single-dose pharmacokinetic study
ModelHuman participants
Sample14 healthy men
Intervention400 mg elemental magnesium as citrate or oxide after magnesium saturation
Duration5-day saturation period and 24-hour post-dose assessment
EndpointsUrinary magnesium excretion; Plasma magnesium

What the study showed, in plain terms

This publication examines urinary magnesium excretion, plasma magnesium. Study population or evidence base: 14 healthy men. Intervention or exposure: 400 mg elemental magnesium as citrate or oxide after magnesium saturation.

Key findings

Citrate produced greater urinary magnesium excretion and higher selected plasma magnesium measurements than oxide.

What this study can and cannot tell us

A small male-only acute study performed after magnesium saturation. Greater circulating exposure does not by itself establish better clinical outcomes.

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Reviewed by the Biohack Blueprint research team

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