Tier 1 — highest

Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPETM Microcapsules) Versus Other Magnesium Sources

David Pajuelo, Justyna M Meissner, Teresa Negra, Alan Connolly, Jose L Mullor
Nutrients 2024 16(24):4367

Bibliography

PubMed
PMID 39770988
PubMed Central
PMC11677548
DOI
10.3390/nu16244367
Funding
Support is recorded from Lubrizol Life Science. See the original publication for grant and material-support details.
Competing interests
The source discloses financial, employment, advisory or material-support relationships involving Lubrizol. See the publication for the authors and nature of each relationship.

Study snapshot

DesignRandomized, double-blind, crossover bioavailability study
ModelHuman participants
Sample40 healthy adults
InterventionMicroencapsulated magnesium compared with oxide, citrate and bisglycinate
DurationAcute measurements through 6 hours after dosing
EndpointsPlasma magnesium; Gastrointestinal tolerability

What the study showed, in plain terms

This publication examines plasma magnesium, gastrointestinal tolerability. Study population or evidence base: 40 healthy adults. Intervention or exposure: Microencapsulated magnesium compared with oxide, citrate and bisglycinate.

Key findings

The microencapsulated preparation produced a more sustained plasma-magnesium increase and favorable tolerability measures in this short comparison.

What this study can and cannot tell us

Branded formulation study using short-term plasma concentrations. The findings cannot establish that all bisglycinate products are poorly absorbed or that one preparation improves clinical outcomes.

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