Tier 2 — strong

Comparing the Bioavailability of Two Seawater-Derived Magnesium Preparations

Brian K McFarlin, Anyla L Paschall, Molly E Kelly, Stephanie M Womack
Journal of medicinal food 2025 28(12):1270-1273

Bibliography

PubMed
PMID 40955524
DOI
10.1177/1096620X251380191
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignDouble-blind, three-period crossover bioavailability study
ModelHuman participants
Sample20 healthy young adults
InterventionRDA-standardized elemental magnesium from seawater-derived citrate or hydroxide, versus placebo
DurationAcute serum testing and 18-hour urine collection
EndpointsUrinary magnesium excretion; Serum magnesium

What the study showed, in plain terms

This publication examines urinary magnesium excretion, serum magnesium. Study population or evidence base: 20 healthy young adults. Intervention or exposure: RDA-standardized elemental magnesium from seawater-derived citrate or hydroxide, versus placebo.

Key findings

Both seawater-derived preparations increased magnesium exposure compared with placebo and did not significantly differ when elemental doses were matched.

What this study can and cannot tell us

Small acute study of specific mineral preparations. Equal elemental doses and clinical outcomes should be distinguished from total compound weight.

Related papers in the corpus

Tier 2
Magnesium bioavailability from magnesium citrate and magnesium oxide
J S Lindberg et al. · Journal of the American College of Nutrition · 1990
Tier 2
Bioavailability of US commercial magnesium preparations
M Firoz et al. · Magnesium research · 2001
Tier 2
Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans
V V Ranade et al. · American journal of therapeutics · 2001
Tier 2
Assessment of bioavailability of Mg from Mg citrate and Mg oxide by measuring urinary excretion in Mg-saturated subjects
Tanja Werner et al. · Magnesium research · 2019
Tier 1
Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPETM Microcapsules) Versus Other Magnesium Sources
David Pajuelo et al. · Nutrients · 2024
Tier 2
Magnesium bioavailability after administration of sucrosomial® magnesium: results of an ex-vivo study and a comparative, double-blinded, cross-over study in healthy subjects
E Brilli et al. · European review for medical and pharmacological sciences · 2018

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research