Tier 2 — strong

Magnesium bioavailability after administration of sucrosomial® magnesium: results of an ex-vivo study and a comparative, double-blinded, cross-over study in healthy subjects

E Brilli, S Khadge, A Fabiano, Y Zambito, T Williams, G Tarantino
European review for medical and pharmacological sciences 2018 22(6):1843-1851

Bibliography

PubMed
PMID 29630135
DOI
10.26355/eurrev_201803_14605
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignHuman double-blind crossover study plus ex vivo intestinal experiments
ModelHuman participants
SampleHealthy adult volunteers and rat intestinal tissue
Intervention350 mg magnesium in sucrosomial, citrate, oxide or bisglycinate formulations
DurationSingle-day testing with washout between formulations
EndpointsBlood, urine and red-cell magnesium; Ex vivo intestinal absorption

What the study showed, in plain terms

This publication examines blood, urine and red-cell magnesium, ex vivo intestinal absorption. Study population or evidence base: Healthy adult volunteers and rat intestinal tissue. Intervention or exposure: 350 mg magnesium in sucrosomial, citrate, oxide or bisglycinate formulations.

Key findings

Sucrosomial magnesium showed greater selected blood, urinary and red-cell responses than some comparator preparations.

What this study can and cannot tell us

Acute bioavailability and ex vivo findings do not establish long-term clinical superiority. Results concern the specific formulations tested.

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