Tier 2 — strong

Effects of betaine-containing nutrients on homocysteine levels and glucose-lipid metabolism in overweight and obese patients with hyperhomocysteinemia

Lishuang Zhang, Yishen Zhang, Di Yang, Chengyan Yang, Xue Rong, Xue Li, Xiaomeng Zhang, Jianping Zhang, Peng Zhang
Nutricion hospitalaria 2026 43(3):553-560

Bibliography

PubMed
PMID 41960847
DOI
10.20960/nh.05892
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled trial
ModelHuman participants
Sample102 included patients from 116 screened; overweight or obesity and elevated homocysteine
InterventionBetaine-containing nutrient formula versus B6, B12 and folic acid treatment
Duration8 weeks
EndpointsHomocysteine; Glucose and lipids; Body measurements

What the study showed, in plain terms

Published in 2026, this source examined homocysteine, methylation and vascular function. Design: Randomized controlled trial. Sample/model: 102 included patients from 116 screened; overweight or obesity and elevated homocysteine. The exposure or intervention was Betaine-containing nutrient formula versus B6, B12 and folic acid treatment. Follow-up or treatment period: 8 weeks.

The betaine-containing regimen produced greater improvements in homocysteine and several metabolic measures than the vitamin comparison.

The abstract does not specify the complete formula or betaine dose. A combined intervention and short follow-up limit attribution and clinical interpretation.

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Continue with TMG and Homocysteine: How Much Can Betaine Lower It?

Key findings

  • The betaine-containing regimen produced greater improvements in homocysteine and several metabolic measures than the vitamin comparison.
  • The recorded outcome domains were Homocysteine; Glucose and lipids; Body measurements.
  • The result applies to the tested exposure: Betaine-containing nutrient formula versus B6, B12 and folic acid treatment; 8 weeks.

What this study can and cannot tell us

  • The abstract does not specify the complete formula or betaine dose. A combined intervention and short follow-up limit attribution and clinical interpretation.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis
Marc P McRae et al. · Journal of chiropractic medicine · 2013
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Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis
Damoon Ashtary-Larky et al. · Critical reviews in food science and nutrition · 2022
Tier 2
Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans
Margreet R Olthof et al. · PLoS medicine · 2005
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Betaine supplementation lowers plasma homocysteine in healthy men and women
Gery R Steenge et al. · The Journal of nutrition · 2003
Tier 2
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women
Margreet R Olthof et al. · The Journal of nutrition · 2003

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology