Tier 1 — highest

Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis

Marc P McRae
Journal of chiropractic medicine 2013 12(1):20-25

Bibliography

PubMed
PMID 23997720
PubMed Central
PMC3610948
DOI
10.1016/j.jcm.2012.11.001
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignMeta-analysis of RCTs
ModelEvidence synthesis; mixed research models
Sample5 randomized trials in healthy adults
InterventionBetaine at least 4 g/day versus control
Duration6-24 weeks across included trials
EndpointsHomocysteine

What the study showed, in plain terms

Published in 2013, this source examined safety assessments and evidence synthesis. Its evidence base was 5 randomized trials in healthy adults. It evaluated Betaine at least 4 g/day versus control across 6-24 weeks across included trials.

Pooled fasting homocysteine was lower by approximately 1.23 micromol/L.

Few short trials and a biomarker endpoint; pooled lowering does not prove cardiovascular prevention.

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Continue with TMG and Homocysteine: How Much Can Betaine Lower It?

Key findings

  • Pooled fasting homocysteine was lower by approximately 1.23 micromol/L.
  • The recorded outcome domains were Homocysteine.
  • This synthesis reuses the included study populations; it is not an additional randomized participant cohort.

What this study can and cannot tell us

  • Few short trials and a biomarker endpoint; pooled lowering does not prove cardiovascular prevention.
  • Pooled estimates depend on the included trials and may share participants with companion publications or other reviews. A statistically significant surrogate outcome does not establish disease prevention.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology