Tier 3 — preclinical

Betaine delays age-related muscle loss by mitigating Mss51-induced impairment in mitochondrial respiration via Yin Yang1

Si Chen, Tongtong He, Jiedong Chen, Dongsheng Wen, Chen Wang, Wenge Huang, Zhijun Yang, Mengtao Yang, Mengchu Li, Siyu Huang, Zihui Huang, Huilian Zhu
Journal of cachexia, sarcopenia and muscle 2024 15(5):2104-2117

Bibliography

PubMed
PMID 39187977
PubMed Central
PMC11446699
DOI
10.1002/jcsm.13558
Funding
Reported funding/support: National Natural Science Youth Foundation of China 10.13039/10001471782204020China Postdoctoral Science Foundation 10.13039/5011000028582022M713556Basic and Applied Basic Research Foundation of Guangdong Province, China2021A1515110848National Natural Science Foundation of China 10.13039/50110000180981773415
Competing interests
Reported disclosure: The authors declare no conflicts of interest.

Study snapshot

DesignExperimental animal and/or laboratory research
ModelAged mice and cultured muscle cells
SampleExperiment-specific biological replicates and model groups; see original methods
InterventionExperimental betaine feeding and cell treatment
Duration12-week mouse intervention with additional mechanistic experiments
EndpointsMuscle function; Mitochondrial respiration; YY1 and Mss51

What the study showed, in plain terms

Published in 2024, this source examined preclinical aging, brain and metabolic mechanisms. Design: Experimental animal and/or laboratory research. Sample/model: Experiment-specific biological replicates and model groups; see original methods. The exposure or intervention was Experimental betaine feeding and cell treatment. Follow-up or treatment period: 12-week mouse intervention with additional mechanistic experiments.

Betaine improved selected muscle and mitochondrial measures, with experiments implicating YY1-mediated suppression of Mss51.

Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.

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Key findings

  • Betaine improved selected muscle and mitochondrial measures, with experiments implicating YY1-mediated suppression of Mss51.
  • The recorded outcome domains were Muscle function; Mitochondrial respiration; YY1 and Mss51.
  • The result applies to the tested exposure: Experimental betaine feeding and cell treatment; 12-week mouse intervention with additional mechanistic experiments.

What this study can and cannot tell us

  • Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology