Tier 4 — mechanistic

Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations

Emilia Zawieja, Agata Chmurzynska
Ageing research reviews 2025 104:102634

Bibliography

PubMed
PMID 39647584
DOI
10.1016/j.arr.2024.102634
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
Reported disclosure: The authors declare no competing interests.

Study snapshot

DesignNarrative review with a structured literature search
ModelEvidence synthesis; mixed research models
SamplePublished literature; no newly enrolled participant cohort
InterventionReview of betaine-related evidence; no single assigned intervention
DurationEvidence review; source-specific study durations vary
EndpointsBetaine biology; Clinical and mechanistic evidence

What the study showed, in plain terms

Published in 2025, this source examined mechanistic and clinical reviews. Its evidence base was Published literature; no newly enrolled participant cohort. It evaluated Review of betaine-related evidence; no single assigned intervention across Evidence review; source-specific study durations vary.

Reviews plausible aging-related pathways involving methylation, mitochondria, muscle and inflammation, while identifying major clinical gaps.

The title describes a narrative review despite systematic-review indexing. It does not establish human lifespan extension or reversal of biological age.

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Key findings

  • Reviews plausible aging-related pathways involving methylation, mitochondria, muscle and inflammation, while identifying major clinical gaps.
  • The recorded outcome domains were Betaine biology; Clinical and mechanistic evidence.

What this study can and cannot tell us

  • The title describes a narrative review despite systematic-review indexing. It does not establish human lifespan extension or reversal of biological age.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Betaine in human nutrition
Stuart A S Craig et al. · The American journal of clinical nutrition · 2004
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Choline and betaine in health and disease
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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology