Tier 4 — mechanistic
Dietary choline and betaine intake minimally impacts rate of annualized cognitive performance throughout the menopause transition: data from the Study of Women's Health Across the Nation
Menopause (New York, N.Y.)
2024
31(10):853-861
Bibliography
- PubMed
- PMID 39078663
- PubMed Central
- PMC11864057
- Funding
- Indexed grant support: U01 CA215834 — NCI NIH HHS — United States. The indexed list may not contain the complete funding declaration.
- Competing interests
- Reported disclosure: Financial disclosure/conflicts of interest: Unrelated to this submission, A.E.C-P. is a member of the Journal of the Academy of Nutrition and Dietetics Board of Editors. R.L.B. has served as a consultant in the past to the NIH Office of Dietary Supplements, Nestlé, the General Mills Bell Institute, RTI International, Think Healthy Group, and Nutrition Impact, is a trustee of the International Food Information Council, and is a former board member of the International Life Sciences Institute–North America. R.L.B. has received travel support to present her research on dietary supplements and was a member of the Journal of Nutrition editorial board. K.C.K. has received past research unrelated to this paper funded by the Bill and Melinda Gates Foundation and Balchem Corp. K.C.K. has served as an independent research consultant for Androvia LifeSciences and ChromaDex. T.C.W. has received competitive unrestricted research grants related from the American Pulse Association, Balchem Corp, Egg Nutrition Center, Florida Citrus, National Dairy Council, National Pork Board, Nestle Health Sciences, New Capstone, Inc, Oak Ridge Institute for Science and Education (ORISE) through the US Army Research Institute for Environmental Medicine, The Simply Good Foods Company, and Reach Global Strategies. T.C.W. receives royalties from the Academy of Nutrition and Dietetics for the editing of the Health Professionals Guide to Dietary Supplements. T.C.W. has received consulting fees from the Academy of Nutrition and Dietetics and National Pork Board. T.C.W. has received honoraria for lectures from the American Society for Nutrition, Berry Health Benefits Symposium, Tea Institute, Amazentis, and Balchem Corp. T.C.W. has received support for attending meetings from the Academy of Nutrition and Dietetics and Brightseed, Inc. T.C.W. is on the science advisory board for AHARA, Beli, Deerland Probiotics & Enzymes, Forbes Health, National Pork Board, and Produce for Better Health Foundation, member of the Brightseed Bioactives Coalition, and a past member of the Academy of Nutrition and Dietetics' Working Group on Flavan-3-ols. T.C.W. is the Editor-in-Chief of the Journal of Dietary Supplements, Deputy Editor-in-Chief of the Journal of the American Nutrition Association, and Nutrition Section Editor of Annals of Medicine. T.C.W. has received in-kind nutrient analyses services from Eurofins USA and is a Senior Fellow of the Center for Magnesium Education and Research. M.S. is an Associate Editor of the Nutrition Section of Annals of Medicine and Frontiers in Neurology, Headache and Neurogenic Pain section. M.S. has received research funding from the Egg Nutrition Center, United States Department of Agriculture, University of Maryland, George Mason University, and the Maryland Soybean Board.
Study snapshot
| Design | Longitudinal cohort analysis |
|---|---|
| Model | Human participants |
| Sample | 1006 women in the SWAN cohort |
| Intervention | Habitual dietary choline and/or betaine intake; no randomized TMG treatment |
| Duration | Repeated annual cognitive assessments |
| Endpoints | Menopause; Verbal memory |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Editorial review
Reviewed by the Biohack Blueprint research team
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