Tier 2 — strong

POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS

Z Rossokha, L Fishchuk, L Sheyko, N Medvedieva, N Gorovenko
Georgian medical news 2020 (309):22-28

Bibliography

PubMed
PMID 33526724
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignComparative clinical intervention
ModelHuman participants
SampleCouples with reproductive disorders; total sample not stated in the indexed abstract
InterventionBetaine-arginine combined with folic acid and B12 versus vitamin treatment without the combination
Duration2 weeks
EndpointsHomocysteine; Vitamin status

What the study showed, in plain terms

Published in 2020, this source examined homocysteine, methylation and vascular function. Design: Comparative clinical intervention. Sample/model: Couples with reproductive disorders; total sample not stated in the indexed abstract. The exposure or intervention was Betaine-arginine combined with folic acid and B12 versus vitamin treatment without the combination. Follow-up or treatment period: 2 weeks.

A larger proportion reached homocysteine below 12 micromol/L with the combined regimen: about 81% versus 50%.

Allocation, dose and full sample details require the original report. No live-birth benefit or independent betaine effect was established.

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Continue with TMG and Homocysteine: How Much Can Betaine Lower It?

Key findings

  • A larger proportion reached homocysteine below 12 micromol/L with the combined regimen: about 81% versus 50%.
  • The recorded outcome domains were Homocysteine; Vitamin status.
  • The result applies to the tested exposure: Betaine-arginine combined with folic acid and B12 versus vitamin treatment without the combination; 2 weeks.

What this study can and cannot tell us

  • Allocation, dose and full sample details require the original report. No live-birth benefit or independent betaine effect was established.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis
Marc P McRae et al. · Journal of chiropractic medicine · 2013
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Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis
Damoon Ashtary-Larky et al. · Critical reviews in food science and nutrition · 2022
Tier 2
Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans
Margreet R Olthof et al. · PLoS medicine · 2005
Tier 2
Betaine supplementation lowers plasma homocysteine in healthy men and women
Gery R Steenge et al. · The Journal of nutrition · 2003
Tier 2
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women
Margreet R Olthof et al. · The Journal of nutrition · 2003

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology