Tier 2 — strong

Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Shane D Scholten, Igor N Sergeev
Open access journal of sports medicine 2013 4:53-61

Bibliography

PubMed
PMID 24379709
PubMed Central
PMC3871649
DOI
10.2147/OAJSM.S39632
Funding
Indexed grant support: P20 RR016479 — NCRR NIH HHS — United States. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled runner trial
ModelHuman intervention research
SampleYoung male endurance runners; sample size not stated in the indexed abstract
InterventionQuercetin 1,000 mg/day or placebo
Duration6 weeks
EndpointsLipid measurements; Oxidative-stress measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2013, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled runner trial. Sample/model: Young male endurance runners; sample size not stated in the indexed abstract. The exposure or intervention was Quercetin 1,000 mg/day or placebo. Follow-up or treatment period: 6 weeks.

A lipid-peroxidation marker decreased, but running performance, oxygen uptake, and other antioxidant measures did not improve.

Biomarker improvement did not translate to measurable performance benefit; sample size requires full-method confirmation.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • A lipid-peroxidation marker decreased, but running performance, oxygen uptake, and other antioxidant measures did not improve.
  • The recorded outcome domains were Lipid measurements; Oxidative-stress measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day or placebo; 6 weeks.

What this study can and cannot tell us

  • Biomarker improvement did not translate to measurable performance benefit; sample size requires full-method confirmation.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials
Daniel Rojano-Ortega et al. · Biology of sport · 2023
Tier 2
Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis
Denis M Pelletier et al. · International journal of sport nutrition and exercise metabolism · 2013
Tier 2
Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study
Jung-Piao Tsao et al. · Frontiers in nutrition · 2022
Tier 2
Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults
Shane D Scholten et al. · Open access journal of sports medicine · 2015
Tier 2
The effects of quercetin supplementation on body composition, exercise performance and muscle damage indices in athletes
Gholamreza Askari et al. · International journal of preventive medicine · 2013

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology