Tier 2 — strong

Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study

Jung-Piao Tsao, Jeffrey R Bernard, Hsiu-Chen Hsu, Chin-Lin Hsu, Su-Fen Liao, I-Shiung Cheng
Frontiers in nutrition 2022 9:875319

Bibliography

PubMed
PMID 35571883
PubMed Central
PMC9096901
DOI
10.3389/fnut.2022.875319
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor MK declared a past collaboration with the authors S-FL, I-SC, and J-PT at the time of review.

Study snapshot

DesignRandomized single-blind placebo-controlled crossover exercise pilot
ModelHuman intervention research
Sample12 healthy physically active adults
InterventionQuercetin 1,000 mg/day or placebo
Duration7 days per condition
EndpointsGlucose and insulin measures; Oxidative-stress measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2022, this source examined exercise and recovery. Design: Randomized single-blind placebo-controlled crossover exercise pilot. Sample/model: 12 healthy physically active adults. The exposure or intervention was Quercetin 1,000 mg/day or placebo. Follow-up or treatment period: 7 days per condition.

Cycling time to exhaustion and selected post-exercise insulin, antioxidant, and recovery measures improved; several other outcomes did not.

Very small, short, single-blind study with multiple endpoints. Mixed results do not establish a consistent performance or metabolic benefit.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Cycling time to exhaustion and selected post-exercise insulin, antioxidant, and recovery measures improved; several other outcomes did not.
  • The recorded outcome domains were Glucose and insulin measures; Oxidative-stress measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day or placebo; 7 days per condition.

What this study can and cannot tell us

  • Very small, short, single-blind study with multiple endpoints. Mixed results do not establish a consistent performance or metabolic benefit.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis
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Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults
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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology