Tier 2 — strong

Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults

Shane D Scholten, Igor N Sergeev, Qingming Song, Chad B Birger
Open access journal of sports medicine 2015 6:229-39

Bibliography

PubMed
PMID 26244032
PubMed Central
PMC4521671
DOI
10.2147/OAJSM.S83159
Funding
Indexed grant support: P20 GM103443 — NIGMS NIH HHS — United States. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized placebo-controlled four-arm supplementation trial
ModelHuman intervention research
Sample40 physically active men
InterventionQuercetin 1,000 mg/day, vitamin D 4,000 IU/day, their combination, or placebo
Duration8 weeks
EndpointsOxidative-stress measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2015, this source examined exercise and recovery. Design: Randomized placebo-controlled four-arm supplementation trial. Sample/model: 40 physically active men. The exposure or intervention was Quercetin 1,000 mg/day, vitamin D 4,000 IU/day, their combination, or placebo. Follow-up or treatment period: 8 weeks.

Neither quercetin nor its combination improved measured physical performance or antioxidant status.

Small arms and generally adequate baseline vitamin D and testosterone. The findings do not support routine hormone or performance enhancement in similar adults.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Neither quercetin nor its combination improved measured physical performance or antioxidant status.
  • The recorded outcome domains were Oxidative-stress measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day, vitamin D 4,000 IU/day, their combination, or placebo; 8 weeks.

What this study can and cannot tell us

  • Small arms and generally adequate baseline vitamin D and testosterone. The findings do not support routine hormone or performance enhancement in similar adults.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials
Daniel Rojano-Ortega et al. · Biology of sport · 2023
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Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis
Denis M Pelletier et al. · International journal of sport nutrition and exercise metabolism · 2013
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Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study
Jung-Piao Tsao et al. · Frontiers in nutrition · 2022
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The effects of quercetin supplementation on body composition, exercise performance and muscle damage indices in athletes
Gholamreza Askari et al. · International journal of preventive medicine · 2013
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Effect of eight weeks of quercetin supplementation on exercise performance, muscle damage and body muscle in male badminton players
Pooya Daneshvar et al. · International journal of preventive medicine · 2013

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology