Tier 2 — strong

Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise

Lisa S McAnulty, Lindsey E Miller, Peter A Hosick, Alan C Utter, John C Quindry, Steven R McAnulty
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2013 38(7):760

Bibliography

PubMed
PMID 23980734
DOI
10.1139/apnm-2012-0455
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled crossover exercise study
ModelHuman intervention research
Sample14 athletes
InterventionResveratrol 120 mg plus quercetin 225 mg/day for 6 days; double those amounts before exercise on day 7
DurationTwo 7-day periods separated by a 1-week washout
EndpointsInflammatory measures; Oxidative-stress measures

What the study showed, in plain terms

Published in 2013, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled crossover exercise study. Sample/model: 14 athletes. The exposure or intervention was Resveratrol 120 mg plus quercetin 225 mg/day for 6 days; double those amounts before exercise on day 7. Follow-up or treatment period: Two 7-day periods separated by a 1-week washout.

The combination blunted the exercise-related rise in F2-isoprostanes but did not improve several other oxidation or inflammatory markers.

Combination effects cannot be assigned to quercetin alone. A redox biomarker change is not evidence of improved athletic performance.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin and Resveratrol Together: Evidence and Practical Choices. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The combination blunted the exercise-related rise in F2-isoprostanes but did not improve several other oxidation or inflammatory markers.
  • The recorded outcome domains were Inflammatory measures; Oxidative-stress measures.
  • The result applies to the tested exposure: Resveratrol 120 mg plus quercetin 225 mg/day for 6 days; double those amounts before exercise on day 7; Two 7-day periods separated by a 1-week washout.

What this study can and cannot tell us

  • Combination effects cannot be assigned to quercetin alone. A redox biomarker change is not evidence of improved athletic performance.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Citation network

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology