Tier 2 — strong

Effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise

Kevin S O'Fallon, Diksha Kaushik, Bozena Michniak-Kohn, C Patrick Dunne, Edward J Zambraski, Priscilla M Clarkson
International journal of sport nutrition and exercise metabolism 2012 22(6):430

Bibliography

PubMed
PMID 22805422
DOI
10.1123/ijsnem.22.6.430
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled eccentric-exercise trial
ModelHuman intervention research
Sample30 healthy adults
InterventionQuercetin 1,000 mg/day in nutrition bars or placebo
Duration7 days before and 5 days after the second exercise session
EndpointsInflammatory measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2012, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled eccentric-exercise trial. Sample/model: 30 healthy adults. The exposure or intervention was Quercetin 1,000 mg/day in nutrition bars or placebo. Follow-up or treatment period: 7 days before and 5 days after the second exercise session.

Quercetin did not improve strength loss, soreness, swelling, creatine kinase, or measured inflammatory responses.

Short muscle-damage experiment. Elevated plasma quercetin did not translate into improved recovery outcomes.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin did not improve strength loss, soreness, swelling, creatine kinase, or measured inflammatory responses.
  • The recorded outcome domains were Inflammatory measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day in nutrition bars or placebo; 7 days before and 5 days after the second exercise session.

What this study can and cannot tell us

  • Short muscle-damage experiment. Elevated plasma quercetin did not translate into improved recovery outcomes.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Citation network

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology