Tier 2 — strong

The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners

Manuela Konrad, David C Nieman, Dru A Henson, Krista M Kennerly, Fuxia Jin, Sandra J Wallner-Liebmann
International journal of sport nutrition and exercise metabolism 2011 21(4):338

Bibliography

PubMed
PMID 21813917
DOI
10.1123/ijsnem.21.4.338
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized placebo-controlled crossover exercise trial
ModelHuman intervention research
Sample20 endurance runners
InterventionMulti-ingredient chews providing quercetin 1,000 mg, EGCG, isoquercetin, omega-3s, vitamin C, and niacinamide
DurationSingle dose 15 minutes before a 2-hour run
EndpointsInflammatory measures; Exposure and pharmacokinetics

What the study showed, in plain terms

Published in 2011, this source examined exercise and recovery. Design: Randomized placebo-controlled crossover exercise trial. Sample/model: 20 endurance runners. The exposure or intervention was Multi-ingredient chews providing quercetin 1,000 mg, EGCG, isoquercetin, omega-3s, vitamin C, and niacinamide. Follow-up or treatment period: Single dose 15 minutes before a 2-hour run.

Plasma quercetin rose strongly, but inflammatory and immune responses did not differ from placebo.

Many active ingredients and an acute schedule. Large exposure increases did not demonstrate a measurable recovery or immune benefit.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Plasma quercetin rose strongly, but inflammatory and immune responses did not differ from placebo.
  • The recorded outcome domains were Inflammatory measures; Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Multi-ingredient chews providing quercetin 1,000 mg, EGCG, isoquercetin, omega-3s, vitamin C, and niacinamide; Single dose 15 minutes before a 2-hour run.

What this study can and cannot tell us

  • Many active ingredients and an acute schedule. Large exposure increases did not demonstrate a measurable recovery or immune benefit.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology