Tier 2 — strong

The dietary flavonoid quercetin increases VO(2max) and endurance capacity

J Mark Davis, Catherine J Carlstedt, Stephen Chen, Martin D Carmichael, E Angela Murphy
International journal of sport nutrition and exercise metabolism 2010 20(1):56

Bibliography

PubMed
PMID 20190352
DOI
10.1123/ijsnem.20.1.56
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled crossover exercise trial
ModelHuman intervention research
Sample12 untrained volunteers
InterventionQuercetin 500 mg twice daily or matched beverage placebo
Duration7 days per treatment
EndpointsExercise performance or recovery

What the study showed, in plain terms

Published in 2010, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled crossover exercise trial. Sample/model: 12 untrained volunteers. The exposure or intervention was Quercetin 500 mg twice daily or matched beverage placebo. Follow-up or treatment period: 7 days per treatment.

Maximal oxygen uptake and cycling time to fatigue increased relative to placebo.

Very small short trial. Other human exercise studies were negative, and this result does not establish long-term fitness or disease-prevention benefits.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Maximal oxygen uptake and cycling time to fatigue increased relative to placebo.
  • The recorded outcome domains were Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 500 mg twice daily or matched beverage placebo; 7 days per treatment.

What this study can and cannot tell us

  • Very small short trial. Other human exercise studies were negative, and this result does not establish long-term fitness or disease-prevention benefits.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study
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Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults
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Citation network

Articles citing this research paper

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology