Tier 2 — strong

Quercetin's influence on exercise performance and muscle mitochondrial biogenesis

David C Nieman, Ashley S Williams, R Andrew Shanely, Fuxia Jin, Steven R McAnulty, N Travis Triplett, Melanie D Austin, Dru A Henson
Medicine and science in sports and exercise 2010 42(2):338

Bibliography

PubMed
PMID 19927026
DOI
10.1249/MSS.0b013e3181b18fa3
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized placebo-controlled crossover exercise trial
ModelHuman intervention research
Sample26 untrained young men
InterventionQuercetin 1,000 mg/day or placebo
Duration2 weeks per period; 2-week washout
EndpointsExercise performance or recovery; Protein activity, binding or signaling

What the study showed, in plain terms

Published in 2010, this source examined exercise and recovery. Design: Randomized placebo-controlled crossover exercise trial. Sample/model: 26 untrained young men. The exposure or intervention was Quercetin 1,000 mg/day or placebo. Follow-up or treatment period: 2 weeks per period; 2-week washout.

A treadmill time trial improved modestly with quercetin; mitochondrial DNA and related gene-expression changes were not statistically significant.

Small short trial with multiple measurements. It does not demonstrate human mitochondrial biogenesis despite the positive performance result.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • A treadmill time trial improved modestly with quercetin; mitochondrial DNA and related gene-expression changes were not statistically significant.
  • The recorded outcome domains were Exercise performance or recovery; Protein activity, binding or signaling.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day or placebo; 2 weeks per period; 2-week washout.

What this study can and cannot tell us

  • Small short trial with multiple measurements. It does not demonstrate human mitochondrial biogenesis despite the positive performance result.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults
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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology