Tier 2 — strong

Dietary quercetin supplementation is not ergogenic in untrained men

Kirk J Cureton, Phillip D Tomporowski, Arpit Singhal, Jeffrey D Pasley, Kevin A Bigelman, Kathleen Lambourne, Jennifer L Trilk, Kevin K McCully, Maurice J Arnaud, Qun Zhao
Journal of applied physiology (Bethesda, Md. : 1985) 2009 107(4):1095

Bibliography

PubMed
PMID 19679747
DOI
10.1152/japplphysiol.00234.2009
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled exercise trial
ModelHuman intervention research
Sample30 recreationally active young men without endurance training
InterventionQuercetin 1,000 mg/day in a sports beverage or placebo
Duration7–16 days
EndpointsOxidative-stress measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2009, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled exercise trial. Sample/model: 30 recreationally active young men without endurance training. The exposure or intervention was Quercetin 1,000 mg/day in a sports beverage or placebo. Follow-up or treatment period: 7–16 days.

Muscle oxidative capacity, oxygen uptake, cycling performance, fatigue, and perceived effort did not improve relative to placebo.

Short intervention in young men. The negative human findings do not support transferring the positive mouse endurance results directly to people.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Muscle oxidative capacity, oxygen uptake, cycling performance, fatigue, and perceived effort did not improve relative to placebo.
  • The recorded outcome domains were Oxidative-stress measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day in a sports beverage or placebo; 7–16 days.

What this study can and cannot tell us

  • Short intervention in young men. The negative human findings do not support transferring the positive mouse endurance results directly to people.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Citation network

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology