Tier 2 — strong

Effects of quercetin and EGCG on mitochondrial biogenesis and immunity

David C Nieman, Dru A Henson, Kendra R Maxwell, Ashley S Williams, Steven R McAnulty, Fuxia Jin, R Andrew Shanely, Thomas C Lines
Medicine and science in sports and exercise 2009 41(7):1467

Bibliography

PubMed
PMID 19516153
DOI
10.1249/MSS.0b013e318199491f
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled multi-arm exercise trial
ModelHuman intervention research
Sample39 trained cyclists
InterventionQuercetin 1,000 mg/day alone or combined with EGCG, isoquercetin, and omega-3 fatty acids
Duration2 weeks before heavy exercise, during exercise, and 1 week afterward
EndpointsInflammatory measures; Protein activity, binding or signaling

What the study showed, in plain terms

Published in 2009, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled multi-arm exercise trial. Sample/model: 39 trained cyclists. The exposure or intervention was Quercetin 1,000 mg/day alone or combined with EGCG, isoquercetin, and omega-3 fatty acids. Follow-up or treatment period: 2 weeks before heavy exercise, during exercise, and 1 week afterward.

The multi-ingredient arm improved selected immune and inflammatory measures; mitochondrial gene-expression outcomes did not differ between groups.

Benefits of the combination cannot be attributed to quercetin alone. Biomarker findings do not demonstrate enhanced mitochondrial biogenesis or performance.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The multi-ingredient arm improved selected immune and inflammatory measures; mitochondrial gene-expression outcomes did not differ between groups.
  • The recorded outcome domains were Inflammatory measures; Protein activity, binding or signaling.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day alone or combined with EGCG, isoquercetin, and omega-3 fatty acids; 2 weeks before heavy exercise, during exercise, and 1 week afterward.

What this study can and cannot tell us

  • Benefits of the combination cannot be attributed to quercetin alone. Biomarker findings do not demonstrate enhanced mitochondrial biogenesis or performance.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology