Tier 2 — strong

Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation

Steven R McAnulty, Lisa S McAnulty, David C Nieman, John C Quindry, Peter A Hosick, Matthew H Hudson, Laura Still, Dru A Henson, Ginger L Milne, Jason D Morrow, Charles L Dumke, Alan C Utter, Nan T Triplett, Adrianna Dibarnardi
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2008 33(2):254

Bibliography

PubMed
PMID 18347680
DOI
10.1139/H07-177
Funding
Indexed grant support: CA 77839 — NCI NIH HHS — United States; DK 48831 — NIDDK NIH HHS — United States; GM 15431 — NIGMS NIH HHS — United States; RR 00095 — NCRR NIH HHS — United States. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized placebo-controlled exercise biomarker trial
ModelHuman intervention research
Sample40 athletes
InterventionQuercetin 1,000 mg/day or placebo
Duration6 weeks before and during three prolonged cycling days
EndpointsInflammatory measures; Oxidative-stress measures

What the study showed, in plain terms

Published in 2008, this source examined exercise and recovery. Design: Randomized placebo-controlled exercise biomarker trial. Sample/model: 40 athletes. The exposure or intervention was Quercetin 1,000 mg/day or placebo. Follow-up or treatment period: 6 weeks before and during three prolonged cycling days.

Exercise increased oxidative and inflammatory markers, and quercetin did not attenuate those responses.

Measured laboratory markers rather than clinical illness or recovery. Related cyclist publications may report overlapping participants.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Exercise increased oxidative and inflammatory markers, and quercetin did not attenuate those responses.
  • The recorded outcome domains were Inflammatory measures; Oxidative-stress measures.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day or placebo; 6 weeks before and during three prolonged cycling days.

What this study can and cannot tell us

  • Measured laboratory markers rather than clinical illness or recovery. Related cyclist publications may report overlapping participants.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study
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Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults
Shane D Scholten et al. · Open access journal of sports medicine · 2015
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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology