Tier 2 — strong

Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA

David C Nieman, Dru A Henson, J Mark Davis, E Angela Murphy, David P Jenkins, Sarah J Gross, Martin D Carmichael, John C Quindry, Charles L Dumke, Alan C Utter, Steven R McAnulty, Lisa S McAnulty, N Travis Triplett, Eugene P Mayer
Journal of applied physiology (Bethesda, Md. : 1985) 2007 103(5):1728

Bibliography

PubMed
PMID 17717114
DOI
10.1152/japplphysiol.00707.2007
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled cyclist biomarker trial
ModelHuman intervention research
Sample40 trained male cyclists
InterventionQuercetin 1,000 mg/day or placebo
Duration3 weeks before and during three prolonged exercise days
EndpointsInflammatory measures; Exercise performance or recovery

What the study showed, in plain terms

Published in 2007, this source examined exercise and recovery. Design: Randomized double-blind placebo-controlled cyclist biomarker trial. Sample/model: 40 trained male cyclists. The exposure or intervention was Quercetin 1,000 mg/day or placebo. Follow-up or treatment period: 3 weeks before and during three prolonged exercise days.

Selected leukocyte cytokine-expression responses decreased, but muscle markers and most plasma cytokine responses did not differ.

Related cyclist reports may share the cohort. Limited molecular changes do not demonstrate improved recovery, immunity, or performance.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Selected leukocyte cytokine-expression responses decreased, but muscle markers and most plasma cytokine responses did not differ.
  • The recorded outcome domains were Inflammatory measures; Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day or placebo; 3 weeks before and during three prolonged exercise days.

What this study can and cannot tell us

  • Related cyclist reports may share the cohort. Limited molecular changes do not demonstrate improved recovery, immunity, or performance.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 1
Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials
Daniel Rojano-Ortega et al. · Biology of sport · 2023
Tier 2
Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis
Denis M Pelletier et al. · International journal of sport nutrition and exercise metabolism · 2013
Tier 2
Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study
Jung-Piao Tsao et al. · Frontiers in nutrition · 2022
Tier 2
Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults
Shane D Scholten et al. · Open access journal of sports medicine · 2015
Tier 2
The effects of quercetin supplementation on body composition, exercise performance and muscle damage indices in athletes
Gholamreza Askari et al. · International journal of preventive medicine · 2013

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology