Tier 2 — strong

Feasibility of telehealth exercise and nicotinamide riboside supplementation in survivors of childhood cancer at risk for diabetes: A pilot randomized controlled trial

Bhandari R, Lukas K, Lee K, Shamunee J, Almeida B, Guzman T, Echevarria M, Lindenfeld L, Nenninger C, Iukuridze A, Albanese S, Rhee JW, Chen S, Brenner C, Wong FL, Armenian SH
Pediatric blood & cancer 2025 72; 1; e31369

Bibliography

PubMed
PMID 39387327
DOI
10.1002/pbc.31369
Funding
Indexed grant support includes NIH HHS. The complete funding declaration is not specified in the accessible abstract.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignRandomized placebo-controlled human trial
ModelHuman participants
Sample20 adult survivors of childhood cancer with prediabetes
InterventionTelehealth exercise with or without NR
Duration6 weeks
EndpointsFeasibility; adherence; glucose and muscle biomarkers

What the study showed, in plain terms

The pilot met enrollment, assessment and adherence feasibility targets. No severe intervention-attributable adverse events were reported.

Key findings

The pilot met enrollment, assessment and adherence feasibility targets. No severe intervention-attributable adverse events were reported.

What this study can and cannot tell us

Not powered for diabetes prevention or clinical efficacy; secondary endpoints did not significantly differ between arms.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology